1887

Abstract

It has previously been suggested that the synthesis of phosphoenolpyruvate carboxykinase (EC 4.1.1.32) in is regulated by a repression-derepression mechanism involving a glycolytic intermediate, and not by induction. Results obtained using compounds that enter the tricarboxylic acid cycle via 2-oxoglutarate, and that can supply both a carbon and a nitrogen source for , suggest it is more likely that the synthesis of phosphoenolpyruvate carboxykinase is inducible, and only weakly regulated by carbon catabolite repression. A similar study of the regulation of the NADP-linked malic enzyme (EC 1.1.1.40) indicates that it too may be inducible.

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1981-04-01
2021-05-17
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References

  1. Armitt S., Mccullough W., Roberts C.F. 1976; Analysis of acetate non-utilizing (acu) mutants inAspergillus nidulans . Journal of General Microbiology 92:263–282
    [Google Scholar]
  2. Arst H.N., Macdonald D.W. 1975; A gene cluster inAspergillus nidulans with an internally located cis-acting regulatory region. Nature; London; 25426–34
    [Google Scholar]
  3. Arst H.N., Parbtari A.A.M., Cove D.J. 1975; A mutant ofAspergillus nidulans defective in NAD-linked glutamate dehydrogenase. Molecular and General Genetics 138:165–171
    [Google Scholar]
  4. Beever R.E. 1975; Regulation of 2-phospho-enolpyruvate carboxykinase and isocitrate lyase syntheses inNeurospora crassa . Journal of General Microbiology 86:197–200
    [Google Scholar]
  5. Clutterbuck A.J., Cove D.J. 1974; Linkage map ofAspergillus nidulans . In CRC Handbook of Microbiology IV pp. 665–676 Laskin A.I., Lechevalier H. Edited by Ohio: CRC Press;
    [Google Scholar]
  6. Cove D.J. 1966; The induction and repression of nitrate reductase in the fungus,Aspergillus nidulans . Biochimica et biophysica acta 113:51–56
    [Google Scholar]
  7. Flavell R.B., Fincham J.R.S. 1968; Acetate nonutilizing mutants ofNeurospora crassa. II. Biochemical deficiencies and the role of certain enzymes. Journal of Bacteriology 95:1063–1068
    [Google Scholar]
  8. Hynes M.J. 1978; Multiple independent control mechanisms affecting the acetamidase ofAspergillus nidulans . Molecular and General Genetics 161:59–65
    [Google Scholar]
  9. Hynes M.J. 1979; Fine structure mapping of the acetamidase structural gene and its controlling region inAspergillus nidulans . Genetics 91:381–392
    [Google Scholar]
  10. Hynes M.J., Kelly J.M. 1977; Pleiotropic mutants ofAspergillus nidulans altered in carbon metabolism. Molecular and General Genetics 150:193–204
    [Google Scholar]
  11. Kelly J.M., Hynes M.J. 1977; Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants ofAspergillus nidulans . Molecular and General Genetics 156:87–92
    [Google Scholar]
  12. Kinghorn J.R., Pateman J.A. 1973; NAD and NADPl-glutamate dehydrogenase activity and ammonium regulation inAspergillus nidulans . Journal of General Microbiology 78:39–46
    [Google Scholar]
  13. Kinghorn J.R., Pateman J.A. 1974; The regulation of NAD-linked glutamate dehydrogenase inAspergillus nidulans . Genetical Research 23:119–124
    [Google Scholar]
  14. Mccullough W., Roberts C.F. 1974; The role of malic enzyme inAspergillus nidulans . FEBS Letters 41:238–242
    [Google Scholar]
  15. Pateman J.A., Rever B.M., Cove D.J. 1967; Genetic and biochemical studies of nitrate reduction inAspergillus nidulans . Biochemical Journal 104:103–111
    [Google Scholar]
  16. Pontecorvo G., Roper J.A., Hemmons L.M., Macdonald K.D., Bufton A.W. 1953; The genetics ofAspergillus nidulans . Advances in Genetics 5:141–238
    [Google Scholar]
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