1887

Abstract

SUMMARY: did not inhibit fusion of lysosomes with the phagocytic vacuoles in infected macrophages and caused no increase in cyclic adenosine 3′: 5′-monophosphate. Glutaraldehyde-killed bacteria showed rapid ultrastructural degeneration within the phagolysosomes. In contrast, untreated bacteria were resistant to digestion by lysosomal enzymes. Intracellular survival of this species appears to depend on resistance to, and not evasion of, lysosomal enzymes.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-110-2-421
1979-02-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/micro/110/2/mic-110-2-421.html?itemId=/content/journal/micro/10.1099/00221287-110-2-421&mimeType=html&fmt=ahah

References

  1. Alexander J., Vickerman K. 1975; Fusion of host cell secondary lysosomes with the parasitophorous vacuoles of Leishmania mexicana-infected macrophages. Journal of Protozoology 22:502–508
    [Google Scholar]
  2. Armstrong J. A., Hart P. D’A. 1971; Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. Journal of Experimental Medicine 134:713–740
    [Google Scholar]
  3. Blanden R. V. 1968; Modification of macrophage function. Journal of the Reticuloendothelial Society 5:179–202
    [Google Scholar]
  4. Chang K.-P., Dwyer D. M. 1976; Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro. Science 193:678–680
    [Google Scholar]
  5. Draper P., Rees R. J. W. 1970; Electron-transparent zone of mycobacteria may be a defence mechanism. Nature, London 228:860–861
    [Google Scholar]
  6. Evans M. J., Levy L. 1972; Ultrastructural changes in cells of the mouse footpad infected with Mycobacterium leprae. Infection and Immunity 5:238–247
    [Google Scholar]
  7. Fauve R. M., Delaunay A. 1966; Résistance cellulaire a l’infection bactérienne. V. Modifications cytoplasmiques observées in vitro, dans des macrophages de souris, après injection de bacteries capables ou non de multiplication intracellulaire. Annales de l’Institut Pasteur 111:Suppl. 578–84
    [Google Scholar]
  8. Friedberg D., Shilo M. 1970; Role of cell wall structure of Salmonella in the interaction with phagocytes. Infection and Immunity 2:279–285
    [Google Scholar]
  9. Friis R. R. 1972; Interaction of L cells and Chlamydia psittaci: entry of the parasite and host responses to its development. Journal of Bacteriology 110:706–721
    [Google Scholar]
  10. Giles K. W., Myers A. 1965; An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature, London 206:93
    [Google Scholar]
  11. Hart P. D’A.,, Armstrong J. A., Brown C. A., Draper P. 1972; Ultrastructural study of the behavior of macrophages toward parasitic mycobacteria. Infection and Immunity 5:803–807
    [Google Scholar]
  12. Hirsch J. G., Fedorko M. E. 1968; Ultrastructure of human leucocytes after simultaneous fixation with glutaraldehyde and osmium tetroxide and ‘post-fixation’ in uranyl acetate. Journal of Cell Biology 38:615–627
    [Google Scholar]
  13. Jones T. C., Hirsch J. G. 1972; The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. Journal of Experimental Medicine 136:1173–1194
    [Google Scholar]
  14. Kress Y., Bloom B. R., Wittner M., Rowen A., Tanowitz H. 1975; Resistance of Trypanosoma cruzi to killing by macrophages. Nature, London 257:394–396
    [Google Scholar]
  15. Kuo J.-F., Greengard P. 1972; An assay method for cyclic AMP and cyclic GMP based upon their abilities to activate cyclic AMP-dependent and cyclic GMP-dependent protein kinases. Advances in Cyclic Nucleotide Research 2:41–50
    [Google Scholar]
  16. Leake E. S., Evans D. G., Myrvik Q. N. 1971; Ultrastructural patterns of bacterial breakdown in normal and granulomatous rabbit alveolar macrophages. Journal of the Reticuloendothelial Society 9:174–199
    [Google Scholar]
  17. Lowrie D. B. 1978; Tubercle bacilli in infected macrophages may inhibit phagosome–lysosome fusion by causing increased cAMP concentrations. In Molecular Biology and Pharmacology of Cyclic Nucleotides, pp. 311–314 Edited by Folco G., Paoletti R. Amsterdam: Elsevier/North Holland;
    [Google Scholar]
  18. Lowrie D. B., Jackett P. S., Ratcliffe N. A. 1975a; Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes. Nature, London 254:600–602
    [Google Scholar]
  19. Lowrie D. B., Jackett P. S., Ratcliffe N. A. 1975b; Failure of phagosome/lysosome fusion in Mycobacterium microti-infected macrophages may be mediated by cyclic AMP of bacterial origin. Proceedings of the Society for General Microbiology 2:74–75
    [Google Scholar]
  20. Lowrie D. B., Aber V. R., Carrol M. E. W. 1979; Division and death rates of Salmonella typhimurium inside macrophages: use of penicillin as a probe. Journal of General Microbiology 110:409–419
    [Google Scholar]
  21. Noguiera N., Cohn Z. 1976; Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells. Journal of Experimental Medicine 143:1402–1420
    [Google Scholar]
  22. Rickenberg H. V. 1974; Cyclic AMP in prokaryotes. Annual Review of Microbiology 28:353–369
    [Google Scholar]
  23. Tagesson C., Stendahl O. 1973; Influence of the cell surface lipopolysaccharide structure of Salmonella typhimurium on resistance to intracellular bactericidal systems. Acta pathologica et microbiologica scondinavica B81:473–480
    [Google Scholar]
  24. Takeuchi A. 1967; Electron microscope studies of experimental salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium. American Journal of Pathology 50:109–136
    [Google Scholar]
  25. Todd W. J., Storz J. 1975; Ultrastructural cytochemical evidence for the activation of lysosomes in the cytocidal effect of Chlamydia psittaci. Infection and Immunity 12:638–646
    [Google Scholar]
  26. Weidner E. 1975; Interactions between Encephalitozoon cuniculi and macrophages. Parasitophorous vacuole growth and the absence of lysosomal fusion. Zeitschrift für Parasitenkunde 47:1–9
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-110-2-421
Loading
/content/journal/micro/10.1099/00221287-110-2-421
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error