1887

Abstract

SUMMARY: Certain single-gene acetate-requiring mutants of are deficient in their ability to oxidize pyruvate directly, but can decarboxylate pyruvate to acetaldehyde and can form ethanol. The growth characteristics of the mutants indicate that they can form acetate from glucose or ethanol. Mutants are inhibited by glucose or sucrose. This glucose inhibition is relieved by the single-gene suppressor mutations and which lower the activity of pyruvic carboxylase, decrease the amount of ethanol formed and permit some growth of and strains in absence of added acetate. The mutation also lowers ethanol dehydrogenase activity, but this activity can be partially restored by growth of strains in the presence of ethanol. As a result of the nearly complete block in their pyruvate metabolism, strains are forced to metabolize glucose by pathways which produce more of the initial respiratory CO from the C-1 carbon of glucose.

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/content/journal/micro/10.1099/00221287-10-2-221
1954-04-01
2019-12-13
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-10-2-221
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