1887

Abstract

A range of silver-coated or -impregnated dressings are now commercially available for use but comparative data on their antimicrobial efficacies are limited. The antibacterial activities of five commercially available silver-coated/impregnated dressings were compared against nine common burn-wound pathogens, namely methicillin-sensitive and -resistant (MRSA), , , , , , and a multi-drug-efflux-positive (BM4454), using a broth culture method. The rapidity and extent of killing of these pathogens under conditions were evaluated. All five silver-impregnated dressings investigated exerted bactericidal activity, particularly against Gram-negative bacteria, including species, species and . The spectrum and rapidity of action, however, ranged widely for different dressings. Acticoat and Contreet had a broad spectrum of bactericidal activities against both Gram-positive and -negative bacteria. Contreet was characterized by a very rapid bactericidal action and achieved a reduction of ⩾10 000 c.f.u. ml in the first 30 min for , , and . Other dressings demonstrated a narrower range of bactericidal activities. Understanding the characteristics of these dressings may enable them to be targeted more appropriately according to the specific requirements for use of a particular dressing, as in for prophylaxis in skin grafting or for an infected wound with MRSA.

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2006-01-01
2021-10-17
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References

  1. Caruso D. M., Foster K. N., Hermans M. H., Rick C. 2004; Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. J Burn Care Rehabil 25:89–97 [CrossRef]
    [Google Scholar]
  2. Darouiche R. O. 1999; Anti-infective efficacy of silver-coated medical prostheses. Clin Infect Dis 29:1371–1377 [CrossRef]
    [Google Scholar]
  3. Fox C. L. Jr 1968; Silver sulphadiazine – a new topical therapy for Pseudomonas in burns. Therapy of Pseudomonas infection in burns Arch Surg 96184–188 [CrossRef]
    [Google Scholar]
  4. Fraser J. F., Bodman J., Sturgess R., Faoagali J., Kimble R. M. 2004; An in vitro study of the anti-microbial efficacy of a 1 % silver sulphadiazine and 0·2 % chlorhexidine digluconate cream, 1 % silver sulphadiazine cream and a silver coated dressing. Burns 30:35–41 [CrossRef]
    [Google Scholar]
  5. Furno F., Morley K. S., Wong B. & 7 other authors; 2004; Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection?. J Antimicrob Chemother 54:1019–1024 [CrossRef]
    [Google Scholar]
  6. Gupta A., Maynes M., Silver S. 1998; Effects of halides on plasmid-mediated silver resistance in Escherichia coli . Appl Environ Microbiol 64:5042–5045
    [Google Scholar]
  7. Heggers J., Goodheart R. E., Washington J., McCoy L., Carino E., Dang T., Edgar P., Maness C., Chinkes D. 2005; Therapeutic efficacy of three silver dressings in an infected animal model. J Burn Care Rehabil 26:53–56 [CrossRef]
    [Google Scholar]
  8. Hilton J. R., Williams D. T., Beuker B., Miller D. R., Harding K. G. 2004; Wound dressings in diabetic foot disease. Clin Infect Dis 39 (Suppl. 2):S100–S103 [CrossRef]
    [Google Scholar]
  9. Jones S. A., Bowler P. G., Walker M., Parsons D. 2004; Controlling wound bioburden with a novel silver-containing Hydrofiber dressing. Wound Repair Regen 12:288–294 [CrossRef]
    [Google Scholar]
  10. Karlsmark T., Agerslev R. H., Bendz S. H., Larsen J. R., Roed-Petersen J., Andersen K. E. 2003; Clinical performance of a new silver dressing, Contreet foam, for chronic exuding venous leg ulcers. J Wound Care 12:351–354 [CrossRef]
    [Google Scholar]
  11. Klasen H. J. 2000; Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 26:117–130 [CrossRef]
    [Google Scholar]
  12. Klaus T., Joerger R., Olsson E., Granqvist C. G. 1999; Silver-based crystalline nanoparticles, microbially fabricated. Proc Natl Acad Sci U S A 96:13611–13614 [CrossRef]
    [Google Scholar]
  13. Lansdown A. B. 2002a; Silver. 1. Its antibacterial properties and mechanism of action. J Wound Care 11:125–130 [CrossRef]
    [Google Scholar]
  14. Lansdown A. B. 2002b). ; Silver. 2. Toxicity in mammals and how its products aid wound repair. J Wound Care 11:173–177 [CrossRef]
    [Google Scholar]
  15. Magnet S., Courvalin P., Lambert T. 2001; Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob Agents Chemother 45:3375–3380 [CrossRef]
    [Google Scholar]
  16. Marshall J. P. II, Schneider R. P. 1977; Systemic argyria secondary to topical silver nitrate. Arch Dermatol 113:1077–1079 [CrossRef]
    [Google Scholar]
  17. Poon V. K., Burd A. 2004; In vitro cytotoxity of silver: implication for clinical wound care. Burns 30:140–147 [CrossRef]
    [Google Scholar]
  18. Ross D. A., Phipps A. J., Clarke J. A. 1993; The use of cerium nitrate-silver sulphadiazine as a topical burns dressing. Br J Plast Surg 46:582–584 [CrossRef]
    [Google Scholar]
  19. Silver S. 2003; Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 27:341–353 [CrossRef]
    [Google Scholar]
  20. Thomas S., McCubbin P. 2003; A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. J Wound Care 12:101–107 [CrossRef]
    [Google Scholar]
  21. White R. J. 2001; An historical overview of the use of silver in wound management. Br J Nurs 10 (15 Suppl. 2):S3–S8
    [Google Scholar]
  22. Wright J. B., Lam K., Burrell R. E. 1998; Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. Am J Infect Control 26:572–577 [CrossRef]
    [Google Scholar]
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