1887

Abstract

The rapidity with which new types of antibiotic resistance can disseminate globally following their initial emergence or recognition is exemplified by the novel carbapenemase New Delhi metallo-β-lactamase (NDM). The first documented case of infection caused by bacteria producing NDM occurred in 2008, although retrospective analyses of stored cultures have identified the gene encoding this enzyme ( ) in isolated in 2006. Since its first description, NDM carbapenemase has been reported from 40 countries worldwide, encompassing all continents except South America and Antarctica. The spread of NDM has a complex epidemiology involving the spread of a variety of species of NDM-positive bacteria and the inter-strain, inter-species and inter-genus transmission of diverse plasmids containing , with the latter mechanism having played a more prominent role to date. The spread of NDM illustrates that antibiotic resistance is a public health problem that transcends national borders and will require international cooperation between health authorities if it is to be controlled.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.052555-0
2013-04-01
2020-07-09
Loading full text...

Full text loading...

/deliver/fulltext/jmm/62/4/499.html?itemId=/content/journal/jmm/10.1099/jmm.0.052555-0&mimeType=html&fmt=ahah

References

  1. Arpin C., Noury P., Boraud D., Coulange L., Manetti A., André C., M’Zali F., Quentin C. 2012; NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel. Antimicrob Agents Chemother 56:3432–3434 [CrossRef][PubMed]
    [Google Scholar]
  2. Bharadwaj R., Joshi S., Dohe V., Gaikwad V., Kulkarni G., Shouche Y. 2012; Prevalence of New Delhi metallo-β-lactamase (NDM-1)-positive bacteria in a tertiary care centre in Pune, India. Int J Antimicrob Agents 39:265–266 [CrossRef][PubMed]
    [Google Scholar]
  3. Birgy A., Doit C., Mariani-Kurkdjian P., Genel N., Faye A., Arlet G., Bingen E. 2011; Early detection of colonization by VIM-1-producing Klebsiella pneumoniae and NDM-1-producing Escherichia coli in two children returning to France. J Clin Microbiol 49:3085–3087 [CrossRef][PubMed]
    [Google Scholar]
  4. Bogaerts P., Verroken A., Jans B., Denis O., Glupczynski Y. 2010; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:831–832 [CrossRef][PubMed]
    [Google Scholar]
  5. Bogaerts P., Rezende de Castro R., Roisin S., Deplano A., Huang T. D., Hallin M., Denis O., Glupczynski Y. 2012; Emergence of NDM-1-producing Acinetobacter baumannii in Belgium. J Antimicrob Chemother 67:1552–1553 [CrossRef][PubMed]
    [Google Scholar]
  6. Bonnin R. A., Poirel L., Carattoli A., Nordmann P. 2012a; Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131. PLoS ONE 7:e34752 [CrossRef][PubMed]
    [Google Scholar]
  7. Bonnin R. A., Poirel L., Naas T., Pirs M., Seme K., Schrenzel J., Nordmann P. 2012b; Dissemination of New Delhi metallo-β-lactamase-1-producing Acinetobacter baumannii in Europe. Clin Microbiol Infect 18:E362–E365 [CrossRef][PubMed]
    [Google Scholar]
  8. Borgia S., Lastovetska O., Richardson D., Eshaghi A., Xiong J., Chung C., Baqi M., McGeer A., Ricci G. other authors 2012; Outbreak of carbapenem-resistant Enterobacteriaceae containing blaNDM-1, Ontario, Canada. Clin Infect Dis 55:e109–e117 [CrossRef][PubMed]
    [Google Scholar]
  9. Boulanger A., Naas T., Fortineau N., Figueiredo S., Nordmann P. 2012; NDM-1-producing Acinetobacter baumannii from Algeria. Antimicrob Agents Chemother 56:2214–2215 [CrossRef][PubMed]
    [Google Scholar]
  10. Brink A. J., Coetzee J., Clay C. G., Sithole S., Richards G. A., Poirel L., Nordmann P. 2012; Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa. J Clin Microbiol 50:525–527 [CrossRef][PubMed]
    [Google Scholar]
  11. Cabanes F., Lemant J., Picot S., Simac C., Cousty J., Jalin L., Naze F., Boisson V., Cresta M. P. other authors 2012; Emergence of Klebsiella pneumoniae and Salmonella metallo-beta-lactamase (NDM-1) producers on Reunion Island. J Clin Microbiol 50:3812 [CrossRef][PubMed]
    [Google Scholar]
  12. Castanheira M., Deshpande L. M., Mathai D., Bell J. M., Jones R. N., Mendes R. E. 2011; Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006–2007. Antimicrob Agents Chemother 55:1274–1278 [CrossRef][PubMed]
    [Google Scholar]
  13. CDC 2010; Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase - United States, 2010. MMWR Morb Mortal Wkly Rep 59:750[PubMed]
    [Google Scholar]
  14. Chan H. L., Poon L. M., Chan S. G., Teo J. W. 2011; The perils of medical tourism: NDM-1-positive Escherichia coli causing febrile neutropenia in a medical tourist. Singapore Med J 52:299–302[PubMed]
    [Google Scholar]
  15. Chen Y., Zhou Z., Jiang Y., Yu Y. 2011; Emergence of NDM-1-producing Acinetobacter baumannii in China. J Antimicrob Chemother 66:1255–1259 [CrossRef][PubMed]
    [Google Scholar]
  16. Chihara S., Okuzumi K., Yamamoto Y., Oikawa S., Hishinuma A. 2011; First case of New Delhi metallo-β-lactamase 1-producing Escherichia coli infection in Japan. Clin Infect Dis 52:153–154 [CrossRef][PubMed]
    [Google Scholar]
  17. Chu Y. W., Tung V. W., Cheung T. K., Chu M. Y., Cheng N., Lai C., Tsang D. N., Lo J. Y. 2011; Carbapenemases in enterobacteria, Hong Kong, China, 2009. Emerg Infect Dis 17:130–132 [CrossRef][PubMed]
    [Google Scholar]
  18. D’Andrea M. M., Venturelli C., Giani T., Arena F., Conte V., Bresciani P., Rumpianesi F., Pantosti A., Narni F., Rossolini G. M. 2011; Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases. J Clin Microbiol 49:2755–2758 [CrossRef][PubMed]
    [Google Scholar]
  19. Denis C., Poirel L., Carricajo A., Grattard F., Fascia P., Verhoeven P., Gay P., Nuti C., Nordmann P. other authors 2012; Nosocomial transmission of NDM-1-producing Escherichia coli within a non-endemic area in France. Clin Microbiol Infect 18:E128–E130 [CrossRef][PubMed]
    [Google Scholar]
  20. Deshpande P., Vadwai V., Shetty A., Dalal R., Soman R., Rodrigues C. 2012; No NDM-1 carriage in healthy persons from Mumbai: reassuring for now. J Antimicrob Chemother 67:1046–1047 [CrossRef][PubMed]
    [Google Scholar]
  21. Dortet L., Nordmann P., Poirel L. 2012a; Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii . Antimicrob Agents Chemother 56:1693–1697 [CrossRef][PubMed]
    [Google Scholar]
  22. Dortet L., Poirel L., Al Yaqoubi F., Nordmann P. 2012b; NDM-1, OXA-48 and OXA-181 carbapenemase-producing Enterobacteriaceae in Sultanate of Oman. Clin Microbiol Infect 18:E144–E148 [CrossRef][PubMed]
    [Google Scholar]
  23. Dortet L., Poirel L., Anguel N., Nordmann P. 2012c; New Delhi metallo-β-lactamase 4-producing Escherichia coli in Cameroon. Emerg Infect Dis 18:1540–1542 [CrossRef][PubMed]
    [Google Scholar]
  24. ECDC 2009 The bacterial challenge: time to react Stockholm: European Centre for Disease Prevention and Control;
    [Google Scholar]
  25. ECDC 2010 EARSS Annual Reports
  26. El-Herte R. I., Araj G. F., Matar G. M., Baroud M., Kanafani Z. A., Kanj S. S. 2012; Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon. J Infect Dev Ctries 6:457–461 [CrossRef][PubMed]
    [Google Scholar]
  27. Espinal P., Fugazza G., López Y., Kasma M., Lerman Y., Malhotra-Kumar S., Goossens H., Carmeli Y., Vila J. 2011; Dissemination of an NDM-2-producing Acinetobacter baumannii clone in an Israeli rehabilitation center. Antimicrob Agents Chemother 55:5396–5398 [CrossRef][PubMed]
    [Google Scholar]
  28. Flateau C., Janvier F., Delacour H., Males S., Ficko C., Andriamanantena D., Jeannot K., Merens A., Rapp C. 2012; Recurrent pyelonephritis due to NDM-1 metallo-beta-lactamase producing Pseudomonas aeruginosa in a patient returning from Serbia, France, 2012. Euro Surveill 17:17[PubMed]
    [Google Scholar]
  29. Fu Y., Du X., Ji J., Chen Y., Jiang Y., Yu Y. 2012; Epidemiological characteristics and genetic structure of blaNDM-1 in non-baumannii Acinetobacter spp. in China. J Antimicrob Chemother 67:2114–2122 [CrossRef][PubMed]
    [Google Scholar]
  30. Gaibani P., Ambretti S., Berlingeri A., Cordovana M., Farruggia P., Panico M., Landini M. P., Sambri V. 2011; Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill 16:20027[PubMed]
    [Google Scholar]
  31. Ghazawi A., Sonnevend A., Bonnin R. A., Poirel L., Nordmann P., Hashmey R., Rizvi T. A., B Hamadeh M., Pál T. 2012; NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates. Clin Microbiol Infect 18:E34–E36 [CrossRef][PubMed]
    [Google Scholar]
  32. Göttig S., Pfeifer Y., Wichelhaus T. A., Zacharowski K., Bingold T., Averhoff B., Brandt C., Kempf V. A. 2010; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:828–829 [CrossRef][PubMed]
    [Google Scholar]
  33. Halaby T., Reuland A. E., Al Naiemi N., Potron A., Savelkoul P. H., Vandenbroucke-Grauls C. M., Nordmann P. 2012; A case of New Delhi metallo-β-lactamase 1 (NDM-1)-producing Klebsiella pneumoniae with putative secondary transmission from the Balkan region in the Netherlands. Antimicrob Agents Chemother 56:2790–2791 [CrossRef][PubMed]
    [Google Scholar]
  34. Hammerum A. M., Toleman M. A., Hansen F., Kristensen B., Lester C. H., Walsh T. R., Fuursted K. 2010; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:829–830 [CrossRef][PubMed]
    [Google Scholar]
  35. Hammerum A. M., Larsen A. R., Hansen F., Justesen U. S., Friis-Møller A., Lemming L. E., Fuursted K., Littauer P., Schønning K. other authors 2012; Patients transferred from Libya to Denmark carried OXA-48-producing Klebsiella pneumoniae, NDM-1-producing Acinetobacter baumannii and meticillin-resistant Staphylococcus aureus . Int J Antimicrob Agents 40:191–192 [CrossRef][PubMed]
    [Google Scholar]
  36. Ho P. L., Lo W. U., Yeung M. K., Lin C. H., Chow K. H., Ang I., Tong A. H., Bao J. Y., Lok S., Lo J. Y. 2011; Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. PLoS ONE 6:e17989 [CrossRef][PubMed]
    [Google Scholar]
  37. Ho P. L., Li Z., Lai E. L., Chiu S. S., Cheng V. C. 2012; Emergence of NDM-1-producing Enterobacteriaceae in China. J Antimicrob Chemother 67:1553–1555 [CrossRef][PubMed]
    [Google Scholar]
  38. Hornsey M., Phee L., Wareham D. W. 2011; A novel variant, NDM-5, of the New Delhi metallo-β-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom. Antimicrob Agents Chemother 55:5952–5954 [CrossRef][PubMed]
    [Google Scholar]
  39. Hrabák J., Stolbová M., Studentová V., Fridrichová M., Chudáčková E., Zemlickova H. 2012; NDM-1 producing Acinetobacter baumannii isolated from a patient repatriated to the Czech Republic from Egypt, July 2011. Euro Surveill 17:17[PubMed]
    [Google Scholar]
  40. Islam M. A., Talukdar P. K., Hoque A., Huq M., Nabi A., Ahmed D., Talukder K. A., Pietroni M. A., Hays J. P. other authors 2012; Emergence of multidrug-resistant NDM-1-producing Gram-negative bacteria in Bangladesh. Eur J Clin Microbiol Infect Dis 31:2593–2600 [CrossRef][PubMed]
    [Google Scholar]
  41. Isozumi R., Yoshimatsu K., Yamashiro T., Hasebe F., Nguyen B. M., Ngo T. C., Yasuda S. P., Koma T., Shimizu K., Arikawa J. 2012; bla NDM-1-positive Klebsiella pneumoniae from environment, Vietnam. Emerg Infect Dis 18:1383–1385[PubMed] [CrossRef]
    [Google Scholar]
  42. Ivanovski N., Masin J., Rambabova-Busljetic I., Pusevski V., Dohcev S., Ivanovski O., Popov Z. 2011; The outcome of commercial kidney transplant tourism in Pakistan. Clin Transplant 25:171–173 [CrossRef][PubMed]
    [Google Scholar]
  43. Jamal W., Rotimi V. O., Albert M. J., Khodakhast F., Udo E. E., Poirel L. 2012; Emergence of nosocomial New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae in patients admitted to a tertiary care hospital in Kuwait. Int J Antimicrob Agents 39:183–184 [CrossRef][PubMed]
    [Google Scholar]
  44. Johnson A. P. 2011; Methicillin-resistant Staphylococcus aureus: the European landscape. J Antimicrob Chemother 66:Suppl. 4iv43–iv48 [CrossRef][PubMed]
    [Google Scholar]
  45. Jovcic B., Lepsanovic Z., Suljagic V., Rackov G., Begovic J., Topisirovic L., Kojic M. 2011; Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia. Antimicrob Agents Chemother 55:3929–3931 [CrossRef][PubMed]
    [Google Scholar]
  46. Kaase M., Nordmann P., Wichelhaus T. A., Gatermann S. G., Bonnin R. A., Poirel L. 2011; NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J Antimicrob Chemother 66:1260–1262 [CrossRef][PubMed]
    [Google Scholar]
  47. Karthikeyan K., Thirunarayan M. A., Krishnan P. 2010; Coexistence of bla OXA-23 with bla NDM-1 and armA in clinical isolates of Acinetobacter baumannii from India. J Antimicrob Chemother 65:2253–2254 [CrossRef][PubMed]
    [Google Scholar]
  48. Kim M. N., Yong D., An D., Chung H. S., Woo J. H., Lee K., Chong Y. 2012; Nosocomial clustering of NDM-1-producing Klebsiella pneumoniae sequence type 340 strains in four patients at a South Korean tertiary care hospital. J Clin Microbiol 50:1433–1436 [CrossRef][PubMed]
    [Google Scholar]
  49. Koh T. H., Khoo C. T., Wijaya L., Leong H. N., Lo Y. L., Lim L. C., Koh T. Y. 2010; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:828 [CrossRef][PubMed]
    [Google Scholar]
  50. Kumarasamy K., Kalyanasundaram A. 2012; Emergence of Klebsiella pneumoniae isolate co-producing NDM-1 with KPC-2 from India. J Antimicrob Chemother 67:243–244 [CrossRef][PubMed]
    [Google Scholar]
  51. Kumarasamy K. K., Toleman M. A., Walsh T. R., Bagaria J., Butt F., Balakrishnan R., Chaudhary U., Doumith M., Giske C. G. other authors 2010; Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597–602 [CrossRef][PubMed]
    [Google Scholar]
  52. Kus J. V., Tadros M., Simor A., Low D. E., McGeer A. J., Willey B. M., Larocque C., Pike K., Edwards I. A. other authors 2011; New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. CMAJ 183:1257–1261 [CrossRef][PubMed]
    [Google Scholar]
  53. Lai C. C., Lin T. L., Tseng S. P., Huang Y. T., Wang J. T., Chang S. C., Teng L. J., Wang J. T., Hsueh P. R. 2011; Pelvic abscess caused by New Delhi metallo-β-lactamase-1-producing Klebsiella oxytoca in Taiwan in a patient who underwent renal transplantation in China. Diagn Microbiol Infect Dis 71:474–475 [CrossRef][PubMed]
    [Google Scholar]
  54. Lascols C., Hackel M., Marshall S. H., Hujer A. M., Bouchillon S., Badal R., Hoban D., Bonomo R. A. 2011; Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009). J Antimicrob Chemother 66:1992–1997 [CrossRef][PubMed]
    [Google Scholar]
  55. Leverstein-Van Hall M. A., Stuart J. C., Voets G. M., Versteeg D., Tersmette T., Fluit A. C. 2010; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:830–831 [CrossRef][PubMed]
    [Google Scholar]
  56. Livermore D. M. 2011; Discovery research: the scientific challenge of finding new antibiotics. J Antimicrob Chemother 66:1941–1944 [CrossRef][PubMed]
    [Google Scholar]
  57. Livermore D. M., Walsh T. R., Toleman M., Woodford N. 2011; Balkan NDM-1: escape or transplant?. Lancet Infect Dis 11:164 [CrossRef][PubMed]
    [Google Scholar]
  58. Mazzariol A., Bošnjak Z., Ballarini P., Budimir A., Bedenić B., Kalenić S., Cornaglia G. 2012; NDM-1-producing Klebsiella pneumoniae, Croatia. Emerg Infect Dis 18:532–534 [CrossRef][PubMed]
    [Google Scholar]
  59. McDermott H., Morris D., McArdle E., O’Mahony G., Kelly S., Cormican M., Cunney R. 2012; Isolation of NDM-1-producing Klebsiella pnemoniae in Ireland, July 2011. Euro Surveill 17:17[PubMed]
    [Google Scholar]
  60. McGann P., Hang J., Clifford R. J., Yang Y., Kwak Y. I., Kuschner R. A., Lesho E. P., Waterman P. E. 2012; Complete sequence of a novel 178-kilobase plasmid carrying bla NDM-1 in a Providencia stuartii strain isolated in Afghanistan. Antimicrob Agents Chemother 56:1673–1679 [CrossRef][PubMed]
    [Google Scholar]
  61. Mochon A. B., Garner O. B., Hindler J. A., Krogstad P., Ward K. W., Lewinski M. A., Rasheed J. K., Anderson K. F., Limbago B. M., Humphries R. M. 2011; New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies. J Clin Microbiol 49:1667–1670 [CrossRef][PubMed]
    [Google Scholar]
  62. Muir A., Weinbren M. J. 2010; New Delhi metallo-β-lactamase: a cautionary tale. J Hosp Infect 75:239–240 [CrossRef][PubMed]
    [Google Scholar]
  63. Mulvey M. R., Grant J. M., Plewes K., Roscoe D., Boyd D. A. 2011; New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada. Emerg Infect Dis 17:103–106 [CrossRef][PubMed]
    [Google Scholar]
  64. Muñoz R., Coffey T. J., Daniels M., Dowson C. G., Laible G., Casal J., Hakenbeck R., Jacobs M., Musser J. M. other authors 1991; Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae . J Infect Dis 164:302–306 [CrossRef][PubMed]
    [Google Scholar]
  65. Mushtaq S., Irfan S., Sarma J. B., Doumith M., Pike R., Pitout J., Livermore D. M., Woodford N. 2011; Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemases. J Antimicrob Chemother 66:2002–2005 [CrossRef][PubMed]
    [Google Scholar]
  66. Nielsen J. B., Hansen F., Littauer P., Schønning K., Hammerum A. M. 2012; An NDM-1-producing Escherichia coli obtained in Denmark has a genetic profile similar to an NDM-1-producing Escherichia coli isolate from the UK. J Antimicrob Chemother 67:2049–2051 [CrossRef][PubMed]
    [Google Scholar]
  67. Nordmann P., Poirel L., Walsh T. R., Livermore D. M. 2011; The emerging NDM carbapenemases. Trends Microbiol 19:588–595 [CrossRef][PubMed]
    [Google Scholar]
  68. Nordmann P., Boulanger A. E., Poirel L. 2012a; NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli . Antimicrob Agents Chemother 56:2184–2186 [CrossRef][PubMed]
    [Google Scholar]
  69. Nordmann P., Dortet L., Poirel L. 2012b; Carbapenem resistance in Enterobacteriaceae: here is the storm!. Trends Mol Med 18:263–272 [CrossRef][PubMed]
    [Google Scholar]
  70. Österblad M., Kirveskari J., Hakanen A. J., Tissari P., Vaara M., Jalava J. 2012; Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008–11). J Antimicrob Chemother 67:2860–2864 [CrossRef][PubMed]
    [Google Scholar]
  71. Oteo J., Domingo-García D., Fernández-Romero S., Saez D., Guiu A., Cuevas O., Lopez-Brea M., Campos J. 2012; Abdominal abscess due to NDM-1-producing Klebsiella pneumoniae in Spain. J Med Microbiol 61:864–867 [CrossRef][PubMed]
    [Google Scholar]
  72. Palmer R. 2010; A disease – or gene – by any other name would cause a stink. Nat Med 16:1059 [CrossRef][PubMed]
    [Google Scholar]
  73. Pasteran F., Albornoz E., Faccone D., Gomez S., Valenzuela C., Morales M., Estrada P., Valenzuela L., Matheu J. other authors 2012; Emergence of NDM-1-producing Klebsiella pneumoniae in Guatemala. J Antimicrob Chemother 67:1795–1797 [CrossRef][PubMed]
    [Google Scholar]
  74. Peirano G., Ahmed-Bentley J., Woodford N., Pitout J. D. 2011a; New Delhi metallo-β-lactamase from traveler returning to Canada. Emerg Infect Dis 17:242–244 [CrossRef][PubMed]
    [Google Scholar]
  75. Peirano G., Pillai D. R., Pitondo-Silva A., Richardson D., Pitout J. D. 2011b; The characteristics of NDM-producing Klebsiella pneumoniae from Canada. Diagn Microbiol Infect Dis 71:106–109 [CrossRef][PubMed]
    [Google Scholar]
  76. Perry J. D., Naqvi S. H., Mirza I. A., Alizai S. A., Hussain A., Ghirardi S., Orenga S., Wilkinson K., Woodford N. other authors 2011; Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media. J Antimicrob Chemother 66:2288–2294 [CrossRef][PubMed]
    [Google Scholar]
  77. Pfeifer Y., Wilharm G., Zander E., Wichelhaus T. A., Göttig S., Hunfeld K. P., Seifert H., Witte W., Higgins P. G. 2011a; Molecular characterization of bla NDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007. J Antimicrob Chemother 66:1998–2001 [CrossRef][PubMed]
    [Google Scholar]
  78. Pfeifer Y., Witte W., Holfelder M., Busch J., Nordmann P., Poirel L. 2011b; NDM-1-producing Escherichia coli in Germany. Antimicrob Agents Chemother 55:1318–1319 [CrossRef][PubMed]
    [Google Scholar]
  79. Poirel L., Hombrouck-Alet C., Freneaux C., Bernabeu S., Nordmann P. 2010a; Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect Dis 10:832 [CrossRef][PubMed]
    [Google Scholar]
  80. Poirel L., Lagrutta E., Taylor P., Pham J., Nordmann P. 2010b; Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Antimicrob Agents Chemother 54:4914–4916 [CrossRef][PubMed]
    [Google Scholar]
  81. Poirel L., Al Maskari Z., Al Rashdi F., Bernabeu S., Nordmann P. 2011a; NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman. J Antimicrob Chemother 66:304–306 [CrossRef][PubMed]
    [Google Scholar]
  82. Poirel L., Benouda A., Hays C., Nordmann P. 2011b; Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco. J Antimicrob Chemother 66:2781–2783 [CrossRef][PubMed]
    [Google Scholar]
  83. Poirel L., Dortet L., Bernabeu S., Nordmann P. 2011c; Genetic features of bla NDM-1-positive Enterobacteriaceae . Antimicrob Agents Chemother 55:5403–5407 [CrossRef][PubMed]
    [Google Scholar]
  84. Poirel L., Fortineau N., Nordmann P. 2011d; International transfer of NDM-1-producing Klebsiella pneumoniae from Iraq to France. Antimicrob Agents Chemother 55:1821–1822 [CrossRef][PubMed]
    [Google Scholar]
  85. Poirel L., Hervé V., Hombrouck-Alet C., Nordmann P. 2011e). Long-term carriage of NDM-1-producing Escherichia coli . J Antimicrob Chemother 66:2185–2186 [CrossRef][PubMed]
    [Google Scholar]
  86. Poirel L., Revathi G., Bernabeu S., Nordmann P. 2011f). Detection of NDM-1-producing Klebsiella pneumoniae in Kenya. Antimicrob Agents Chemother 55:934–936 [CrossRef][PubMed]
    [Google Scholar]
  87. Poirel L., Ros A., Carricajo A., Berthelot P., Pozzetto B., Bernabeu S., Nordmann P. 2011g). Extremely drug-resistant Citrobacter freundii isolate producing NDM-1 and other carbapenemases identified in a patient returning from India. Antimicrob Agents Chemother 55:447–448 [CrossRef][PubMed]
    [Google Scholar]
  88. Poirel L., Schrenzel J., Cherkaoui A., Bernabeu S., Renzi G., Nordmann P. 2011h). Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland. J Antimicrob Chemother 66:1730–1733 [CrossRef][PubMed]
    [Google Scholar]
  89. Poirel L., Bonnin R. A., Boulanger A., Schrenzel J., Kaase M., Nordmann P. 2012a; Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii . Antimicrob Agents Chemother 56:1087–1089 [CrossRef][PubMed]
    [Google Scholar]
  90. Poirel L., Lascols C., Bernabeu S., Nordmann P. 2012b; NDM-1-producing Klebsiella pneumoniae in Mauritius. Antimicrob Agents Chemother 56:598–599 [CrossRef][PubMed]
    [Google Scholar]
  91. Poirel L., Ozdamar M., Ocampo-Sosa A. A., Türkoglu S., Ozer U. G., Nordmann P. 2012c; NDM-1-producing Klebsiella pneumoniae now in Turkey. Antimicrob Agents Chemother 56:2784–2785 [CrossRef][PubMed]
    [Google Scholar]
  92. Rimrang B., Chanawong A., Lulitanond A., Wilailuckana C., Charoensri N., Sribenjalux P., Phumsrikaew W., Wonglakorn L., Kerdsin A., Chetchotisakd P. 2012; Emergence of NDM-1- and IMP-14a-producing Enterobacteriaceae in Thailand. J Antimicrob Chemother 67:2626–2630 [CrossRef][PubMed]
    [Google Scholar]
  93. Rogers B. A., Sidjabat H. E., Paterson D. L. 2011; Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain. J Antimicrob Chemother 66:1–14 [CrossRef][PubMed]
    [Google Scholar]
  94. Roy S., Singh A. K., Viswanathan R., Nandy R. K., Basu S. 2011a; Transmission of imipenem resistance determinants during the course of an outbreak of NDM-1 Escherichia coli in a sick newborn care unit. J Antimicrob Chemother 66:2773–2780 [CrossRef][PubMed]
    [Google Scholar]
  95. Roy S., Viswanathan R., Singh A. K., Das P., Basu S. 2011b; Sepsis in neonates due to imipenem-resistant Klebsiella pneumoniae producing NDM-1 in India. J Antimicrob Chemother 66:1411–1413 [CrossRef][PubMed]
    [Google Scholar]
  96. Samuelsen O., Thilesen C. M., Heggelund L., Vada A. N., Kümmel A., Sundsfjord A. 2011; Identification of NDM-1-producing Enterobacteriaceae in Norway. J Antimicrob Chemother 66:670–672 [CrossRef][PubMed]
    [Google Scholar]
  97. Savard P., Gopinath R., Zhu W., Kitchel B., Rasheed J. K., Tekle T., Roberts A., Ross T., Razeq J. other authors 2011; First NDM-positive Salmonella sp. strain identified in the United States. Antimicrob Agents Chemother 55:5957–5958 [CrossRef][PubMed]
    [Google Scholar]
  98. Seema K., Ranjan Sen M., Upadhyay S., Bhattacharjee A. 2011; Dissemination of the New Delhi metallo-β-lactamase-1 (NDM-1) among Enterobacteriaceae in a tertiary referral hospital in north India. J Antimicrob Chemother 66:1646–1647 [CrossRef][PubMed]
    [Google Scholar]
  99. Sekizuka T., Matsui M., Yamane K., Takeuchi F., Ohnishi M., Hishinuma A., Arakawa Y., Kuroda M. 2011; Complete sequencing of the bla NDM-1-positive IncA/C plasmid from Escherichia coli ST38 isolate suggests a possible origin from plant pathogens. PLoS ONE 6:e25334 [CrossRef][PubMed]
    [Google Scholar]
  100. Shaheen B. W., Nayak N., Boothe M. 2012; First reported case of New Delhi metallo (NDM) carbapenem-positive gene in Escherichia coli from companion animals in the United States. In Abstracts of the 52nd ICAAC abstract C2–1219 San Francisco, CA: American Society for Microbiology;
    [Google Scholar]
  101. Sidjabat H., Nimmo G. R., Walsh T. R., Binotto E., Htin A., Hayashi Y., Li J., Nation R. L., George N., Paterson D. L. 2011; Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-β-lactamase. Clin Infect Dis 52:481–484 [CrossRef][PubMed]
    [Google Scholar]
  102. Solé M., Pitart C., Roca I., Fàbrega A., Salvador P., Muñoz L., Oliveira I., Gascón J., Marco F., Vila J. 2011; First description of an Escherichia coli strain producing NDM-1 carbapenemase in Spain. Antimicrob Agents Chemother 55:4402–4404 [CrossRef][PubMed]
    [Google Scholar]
  103. Stefani S., Chung D. R., Lindsay J. A., Friedrich A. W., Kearns A. M., Westh H., Mackenzie F. M. 2012; Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods. Int J Antimicrob Agents 39:273–282 [CrossRef][PubMed]
    [Google Scholar]
  104. Struelens M. J., Monnet D. L., Magiorakos A. P., Santos O’Connor F., Giesecke J. European NDM-1 Survey Participants 2010; New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe. Euro Surveill 15:15[PubMed]
    [Google Scholar]
  105. Sykes R. 2010; The 2009 Garrod lecture: the evolution of antimicrobial resistance: a Darwinian perspective. J Antimicrob Chemother 65:1842–1852 [CrossRef][PubMed]
    [Google Scholar]
  106. TATFAR 2012 Recommendations for future collaboration between the U.S. and EU. Transatlantic Taskforce on Antimicrobial Resistance, 2011 Stockholm: ECDC;
    [Google Scholar]
  107. Tijet N., Alexander D. C., Richardson D., Lastovetska O., Low D. E., Patel S. N., Melano R. G. 2011; New Delhi metallo-β-lactamase, Ontario, Canada. Emerg Infect Dis 17:306–307 [CrossRef][PubMed]
    [Google Scholar]
  108. Tsang K. Y., Luk S., Lo J. Y., Tsang T. Y., Lai S. T., Ng T. K. 2012; Hong Kong experiences the ‘ultimate superbug’: NDM-1 Enterobacteriaceae . Hong Kong Med J 18:439–441[PubMed]
    [Google Scholar]
  109. van der Bij A. K., Pitout J. D. 2012; The role of international travel in the worldwide spread of multiresistant Enterobacteriaceae . J Antimicrob Chemother 67:2090–2100 [CrossRef][PubMed]
    [Google Scholar]
  110. Walsh T. R., Toleman M. A. 2011; The new medical challenge: why NDM-1? Why Indian?. Expert Rev Anti Infect Ther 9:137–141 [CrossRef][PubMed]
    [Google Scholar]
  111. Walsh T. R., Toleman M. A. 2012; The emergence of pan-resistant Gram-negative pathogens merits a rapid global political response. J Antimicrob Chemother 67:1–3 [CrossRef][PubMed]
    [Google Scholar]
  112. Walsh T. R., Weeks J., Livermore D. M., Toleman M. A. 2011; Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 11:355–362 [CrossRef][PubMed]
    [Google Scholar]
  113. Wang Y., Wu C., Zhang Q., Qi J., Liu H., Wang Y., He T., Ma L., Lai J. other authors 2012; Identification of New Delhi metallo-β-lactamase 1 in Acinetobacter lwoffii of food animal origin. PLoS ONE 7:e37152 [CrossRef][PubMed]
    [Google Scholar]
  114. WHO 2012 The Evolving Threat of Antimicrobial Resistance: Options for Action Geneva: World Health Organization;
    [Google Scholar]
  115. Williamson D. A., Sidjabat H. E., Freeman J. T., Roberts S. A., Silvey A., Woodhouse R., Mowat E., Dyet K., Paterson D. L. other authors 2012; Identification and molecular characterisation of New Delhi metallo-β-lactamase-1 (NDM-1)- and NDM-6-producing Enterobacteriaceae from New Zealand hospitals. Int J Antimicrob Agents 39:529–533 [CrossRef][PubMed]
    [Google Scholar]
  116. Wise R., Blaser M., Carrs O., Cassell G., Fishman N., Guidos R., Levy S., Powers J., Norrby R. other authors 2011; The urgent need for new antibacterial agents. J Antimicrob Chemother 66:1939–1940 [CrossRef][PubMed]
    [Google Scholar]
  117. Woodford N., Turton J. F., Livermore D. M. 2011; Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 35:736–755 [CrossRef][PubMed]
    [Google Scholar]
  118. Wu H. S., Chen T. L., Chen I. C., Huang M. S., Wang F. D., Fung C. P., Lee S. D. 2010; First identification of a patient colonized with Klebsiella pneumoniae carrying bla NDM-1 in Taiwan. J Chin Med Assoc 73:596–598 [CrossRef][PubMed]
    [Google Scholar]
  119. Yang J., Chen Y., Jia X., Luo Y., Song Q., Zhao W., Wang Y., Liu H., Zheng D. other authors 2012; Dissemination and characterization of NDM-1-producing Acinetobacter pittii in an intensive care unit in China. Clin Microbiol Infect 18:E506–E513[PubMed] [CrossRef]
    [Google Scholar]
  120. Yong D., Toleman M. A., Giske C. G., Cho H. S., Sundman K., Lee K., Walsh T. R. 2009; Characterization of a new metallo-beta-lactamase gene, bla NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53:5046–5054 [CrossRef][PubMed]
    [Google Scholar]
  121. Zarfel G., Hoenigl M., Leitner E., Salzer H. J., Feierl G., Masoud L., Valentin T., Krause R., Grisold A. J. 2011a; Emergence of New Delhi metallo-β-lactamase, Austria. Emerg Infect Dis 17:129–130 [CrossRef][PubMed]
    [Google Scholar]
  122. Zarfel G., Hoenigl M., Würstl B., Leitner E., Salzer H. J., Valentin T., Posch J., Krause R., Grisold A. J. 2011b; Emergence of carbapenem-resistant Enterobacteriaceae in Austria, 2001–2010. Clin Microbiol Infect 17:E5–E8 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.052555-0
Loading
/content/journal/jmm/10.1099/jmm.0.052555-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error