1887

Abstract

At present, few data are available on the prevalence and antifungal susceptibility of complex isolates from HIV-infected individuals. The complex comprises three species, , and . Fifteen of 318 isolates were identified as members of the complex by PCR and restriction fragment length polymorphism (RFLP). The prevalence of complex isolates was 4.7 %, 2.2 % being identified as and 2.5 % as , while no was isolated. This is believed to be the first study that has identified isolates of obtained from the oral cavity of HIV-infected individuals. Antifungal susceptibility tests indicated that all the isolates were susceptible to amphotericin B (AMB), fluconazole (FLC), ketoconazole (KTC), itraconazole (ITC), voriconazole (VRC) and caspofungin (CASPO). Although isolates of and were susceptible to FLC, isolates of showed a tendency for higher MICs (≥1.0 µg ml). Based upon the frequency of candidiasis and the fact that certain isolates of the complex respond differently to FLC therapy, our data may be of therapeutic relevance with respect to susceptibility and potential resistance to specific antifungal agents. Our data suggest that can be a human commensal; its importance as a pathogen has yet to be confirmed.

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2012-12-01
2019-10-21
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