1887

Abstract

This study aimed to evaluate the distribution of superantigen gene profiles and the presence of exfoliative toxin genes in community-acquired meticillin-resistant (CA-MRSA) isolated from Chinese children, and simultaneously to assess virulence gene profiles and genetic background. Of the CA-MRSA isolates, 88.9 % (88/99) harboured toxin genes, with as the most frequent toxin gene (62.6 %), followed by (61.6 %), (60.6 %) and (35.4 %). The gene was detected only in one ST398-IVa- t034 strain. The and genes were not found in any of the isolates tested. A total of 38 virulence genotypes were observed, of which the genotype (27.3 %, 24/88) comprised the majority, followed by (18.2 %, 16/88). The enterotoxin gene cluster including predominated at a rate of 15.1 %. The relationship among toxin genotypes, toxin genes encoding profiles of mobile genetic elements and genetic background was analysed. Among 66 clonal complex (CC) 59 isolates, 87.9 % (58/66) were positive for toxin genes, and 75.8 % (50/66) harboured the toxin gene combination . Among -positive CC59 strains, 42.0 % (21/50) also carried the gene. CC59 corresponded exclusively to accessory gene regulator 1 (). The data presented here enhance our current knowledge on the virulence determinants of CA-MRSA.

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2011-01-01
2019-10-18
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