1887

Abstract

Thymol (THY) was found to have antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of , standard strain ATCC 10231 and one experimentally induced FLC-resistant S-1. In addition, synergism was observed for clinical isolates of with combinations of THY–FLC and THY–amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and ΔE models]. The interaction between THY–FLC or THY–AMB in FLC-resistant and -susceptible strains of showed a high percentage of synergism by the FICI method and the Δ method. The ΔE model gave results consistent with FICI, and no antagonistic action was observed in the strains tested.

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2009-08-01
2020-10-21
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