%0 Journal Article %A Guo, Na %A Liu, Jingbo %A Wu, Xiuping %A Bi, Xingming %A Meng, Rizeng %A Wang, Xuelin %A Xiang, Hua %A Deng, Xuming %A Yu, Lu %T Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans %D 2009 %J Journal of Medical Microbiology, %V 58 %N 8 %P 1074-1079 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.008052-0 %K FICI, fractional inhibitory concentration index %K THY, thymol %K LA, Loewe additivity %K FLC, fluconazole %K BI, Bliss independence %K CLSI, Clinical and Laboratory Standards Institute %K AMB, amphotericin B %K ATCC, American Type Culture Collection %I Microbiology Society, %X Thymol (THY) was found to have in vitro antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of Candida albicans, standard strain ATCC 10231 and one experimentally induced FLC-resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans with combinations of THY–FLC and THY–amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and ΔE models]. The interaction between THY–FLC or THY–AMB in FLC-resistant and -susceptible strains of C. albicans showed a high percentage of synergism by the FICI method and the ΔE method. The ΔE model gave results consistent with FICI, and no antagonistic action was observed in the strains tested. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.008052-0