1887

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Volume 71, Issue 9

Microbiological and molecular screening of spp. isolated from genital tract of asymptomatic pregnant women No Access

Abstract

spp. may cause opportunistic infections called vulvovaginal candidiasis (VVC), which is estimated to be the second most common cause of vaginitis worldwide.

Under various circumstances, VVC could compromise pregnancy outcomes. Emerging data suggests that VVC during pregnancy may be associated with increased risk of complications and congenital cutaneous candidiasis.

To assess the prevalence of spp. in asymptomatic pregnant women and determine the susceptibility of the isolates to antifungal drugs.

In a prospective cohort, 65 high vaginal swab samples of consented pregnant women. isolates were identified using both microbiological and molecular tools and drug susceptibilities were profiled.

The prevalence of VVC among our study participants was 37 %, 24 of the 65 asymptomatic pregnant women show spp. colonization. was the most common species 61 %, followed by 39 %. In addition, a significant fraction of the isolated colonies showed resistance to Fluconazole, with a ratio of 63 % for isolates and 16 % for isolates. Moreover, relative quantification of genes related to resistance to fluconazole, CDR1, ERG11 as well as HWP1, showed a significant change compared to controls.

Monitoring of vaginal olonization before the third trimester of pregnancy, that could reduce congenital colonization and risk of pregnancy complications.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Candida albicans , Candida glabrata , Candida spp. colonization , fluconazole resistance , in-vitro antifungal susceptibility and pregnant asymptomatic women
© 2022 The Authors
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2022-09-20
2024-04-29
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Microbiological and molecular screening of Candida spp. isolated from genital tract of asymptomatic pregnant women
J. Med. Microbiol. 71, 001589 (2022); https://doi.org/10.1099/jmm.0.001589
/content/journal/jmm/10.1099/jmm.0.001589
/content/journal/jmm/10.1099/jmm.0.001589
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