1887

Abstract

The options available for treating infections with carbapenemase-producing (CPE) are limited; with the increasing threat of these infections, new treatments are urgently needed. Biapenem (BIPM) is a carbapenem, and limited data confirming its killing effect against CPE are available. In this study, we examined the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of BIPM for 14 IMP-1-producing strains isolated from the Okayama region in Japan. The MICs against almost all the isolates were lower than 0.5 µg ml, indicating susceptibility to BIPM, while approximately half of the isolates were confirmed to be bacteriostatic to BIPM. However, initial killing to a 99.9 % reduction was observed in seven out of eight strains in a time–kill assay. Despite the small data set, we concluded that the efficacy of BIPM suggests that the drug could be a new therapeutic option against infection with IMP-producing CPE.

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2021-10-04
2021-10-17
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