1887

Abstract

is the most frequently identified enteric pathogen in patients with nosocomial antibiotic-associated diarrhoea and pseudomembranous colitis. Several clinically isolated strains are resistant to antibiotics other than metronidazole and vancomycin. Recently, bacteriocins of lactic acid bacteria have been proposed as an alternative or complementary treatment. The aim of this study was to investigate the inhibitory effect of nisin, a bacteriocin produced by several strains of , against clinical isolates of . Nisin Z obtained from culture of subsp. biovar. was tested along with commercial nisin A. The effect of nisin A on spores was also examined. Nisin A and Z both inhibited the growth of all isolates, and MICs were estimated at 6.2 μg ml for nisin Z and 0.8 μg ml for nisin A. In addition, spores were also susceptible to nisin A (25.6 μg ml), which reduced spore viability by 40–50 %. These results suggested that nisin and hence nisin-producing strains could be used to treat -associated diarrhoea.

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2016-02-01
2021-10-20
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