The susceptibility of a strain of to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied . Albendazole was the most active compound, with a 50% inhibitory concentration (IC50) of 0·01 mg/L and a minimal lethal concentration (MLC) of < 0·04 mg/L; the IC50 of mebendazole was 0·06 mg/L and the MLC < 0·5 mg/L. Among the 5-nitroimidazoles tested, ornidazole was the most effective (IC50 0·12 mg/L); tinidazole, metronidazole, secnidazole and hemezole were less active. Nifuroxazide, etofamide and nalidixic acid exhibited modest anti-giardial activity; quinfamide did not inhibit the growth of the parasite at a concentration of 200 mg/L. Albendazole and mebendazole are promising candidates for clinical use and should be further evaluated.


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