1887

Abstract

Summary

The susceptibility of a strain of to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied . Albendazole was the most active compound, with a 50% inhibitory concentration (IC50) of 0.01 mg/L and a minimal lethal concentration (MLC) of < 0.04 mg/L; the IC50 of mebendazole was 0.06 mg/L and the MLC < 0.5 mg/L. Among the 5-nitroimidazoles tested, ornidazole was the most effective (IC50 0.12 mg/L); tinidazole, metronidazole, secnidazole and hemezole were less active. Nifuroxazide, etofamide and nalidixic acid exhibited modest anti-giardial activity; quinfamide did not inhibit the growth of the parasite at a concentration of 200 mg/L. Albendazole and mebendazole are promising candidates for clinical use and should be further evaluated.

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1992-09-01
2022-10-01
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