@article{mbs:/content/journal/jmm/10.1099/00222615-37-3-221, author = "Cedillo-Rivera, R. and Muñoz, O.", title = "In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents", journal= "Journal of Medical Microbiology", year = "1992", volume = "37", number = "3", pages = "221-224", doi = "https://doi.org/10.1099/00222615-37-3-221", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-37-3-221", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary The susceptibility of a strain of Giardia lamblia to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied in vitro. Albendazole was the most active compound, with a 50% inhibitory concentration (IC50) of 0.01 mg/L and a minimal lethal concentration (MLC) of < 0.04 mg/L; the IC50 of mebendazole was 0.06 mg/L and the MLC < 0.5 mg/L. Among the 5-nitroimidazoles tested, ornidazole was the most effective (IC50 0.12 mg/L); tinidazole, metronidazole, secnidazole and hemezole were less active. Nifuroxazide, etofamide and nalidixic acid exhibited modest anti-giardial activity; quinfamide did not inhibit the growth of the parasite at a concentration of 200 mg/L. Albendazole and mebendazole are promising candidates for clinical use and should be further evaluated.", }