1887

Abstract

Summary

Non-motile variants of (strain 26695) occurred with a frequency of 1.6 (SD 0.4) × 10 variants/cell/division cycle, and reversion to the motile form occurred with a frequency of < 10 variants/cell/division cycle. The two forms remained > 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. Bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile , but from only two of eight inoculated with the non-motile variant. The motile form survived for 21 days in infected piglets, but the non-motile variant survived for only 6 days. Bacteria recovered from piglets inoculated with the non-motile variant were non-motile. These data support the hypothesis that motility is a colonisation factor for

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-37-2-123
1992-08-01
2022-01-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/37/2/medmicro-37-2-123.html?itemId=/content/journal/jmm/10.1099/00222615-37-2-123&mimeType=html&fmt=ahah

References

  1. Marshall B. J., Warren J. R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1:1311–1314
    [Google Scholar]
  2. Krakowka S., Morgan D. R., Kraft W. G., Leunk R. D. Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 1987; 55:2789–2796
    [Google Scholar]
  3. Eaton K. A., Morgan D. R., Krakowka S. Persistence of Hel icobacter pylori in conventionalized piglets. J Infect Dis 1990; 161:1299–1301
    [Google Scholar]
  4. Eaton K. A., Morgan D. R., Krakowka S. Campylobacter pylori virulence factors in gnotobiotic piglets. Infect Immun 1989; 57:1119–1125
    [Google Scholar]
  5. Eaton K. A., Brooks C. L., Morgan D. R., Krakowka S. Essential role of urease in the pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 1991; 59:2470–2475
    [Google Scholar]
  6. Owen R. J., Costas M., Morgan D. D. Strain variation in Campylobacter pylori detected by numerical analysis of one-dimensional electrophoretic protein patterns. Antonie Van Leeuwenhoek 1989; 55:253–267
    [Google Scholar]
  7. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680–685
    [Google Scholar]
  8. Caldwell M. B., Guerry P., Lee E. C., Burans J. P., Walker R. I. Reversible expression of flagella in Campylobacter jejuni . Infect Immun 1985; 50:941–943
    [Google Scholar]
  9. Silverman M., Zieg J., Hilmen M., Simon M. Phase variation in Salmonella: genetic analysis of a recombinational switch. Proc Natl Acad Sci USA 1979; 76:391–395
    [Google Scholar]
  10. Attridge S. R., Rowley D. The role of the flagellum in the adherence of Vibrio cholerae . J Infect Dis 1983; 147:864–872
    [Google Scholar]
  11. Guenzel M. N., Berry L. J. Motility as a virulence factor for Vibrio cholerae . Infect Immun 1975; 11:890–897
    [Google Scholar]
  12. Morooka T., Umeda A., Amako K. Motility as an intestinal colonization factor for Campylobacter jejuni . J Gen Microbiol 1985; 131:1973–1980
    [Google Scholar]
  13. Carsiotis M., Weinstein D. L., Karch H., Holder I. A., O’brien A. D. Flagella of Salmonella typhimurium are a virulence factor in infected c57b1/6j mice. Infect Immun 1984; 46:814–818
    [Google Scholar]
  14. Freter R. Mechanisms of bacterial colonization of the mucosal surfaces of the gut. In Roth J. A. (ed) Virulence mechanisms of bacterial pathogens Washington D. C.: American Society for Microbiology; 198845–60
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-37-2-123
Loading
/content/journal/jmm/10.1099/00222615-37-2-123
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error