1887

Abstract

Summary

Pefloxacin and fleroxacin showed biphasic bactericidal activity against KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, an inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxacin and fleroxacin were also active against non-dividing KL16. There fore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-32-2-83
1990-06-01
2024-12-02
Loading full text...

Full text loading...

/deliver/fulltext/jmm/32/2/medmicro-32-2-83.html?itemId=/content/journal/jmm/10.1099/00222615-32-2-83&mimeType=html&fmt=ahah

References

  1. Phillips I., King A., Shannon K. In vitro properties of the quinolones. In Andriole V T. ed The quinolones. London: Academic Press; 198883–118
    [Google Scholar]
  2. Paganoni R., Herzog C., Braunsteiner A., Hohl P. Fleroxacin: in-vitro activity worldwide against 20,807 clinical isolates and comparison to ciprofloxacin and norfloxa-cin. J Antimicrob Chemother 1988; 22: Suppl D 3–17
    [Google Scholar]
  3. Gonzalez J P., Henwood J M. Pefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 1989; 37:628–668
    [Google Scholar]
  4. Smith J T. Awakening the slumbering potential of the 4-quinolone antibacterials. Pharm J 1984; 233:299–305
    [Google Scholar]
  5. Smith J T., Lewin C S. Chemistry and mechanisms of action of the quinolone antibacterials. In Andriole V T. ed The quinolones. London: Academic Press; 198823–82
    [Google Scholar]
  6. Dietz W H., Cook T M., Goss W A. Mechanism of action of nalidixic acid on Escherichia coli: III. Conditions required for lethality. J Bacteriol 1966; 61:768–773
    [Google Scholar]
  7. Lewin C S., Amyes S G B. Bactericidal activity of DR-3355 an optically active isomer of ofloxacin. J Med Microbiol 1989; 30:227–231
    [Google Scholar]
  8. Lewin C S., Amyes S G B., Smith J T. Bactericidal activity of enoxacin and lomefloxacin against Escherichia coli KL16. Eur J Clin Microbiol Infect Dis 1989; 8:731–733
    [Google Scholar]
  9. Ratcliffe N T., Smith J T. Norfloxacin has a novel bactericidal mechanism unrelated to that of other 4- quinolones. J Pharm Pharmacol 1985; 37:92
    [Google Scholar]
  10. Zeiler H-J., Grohe K. The in vitro and in vivo activity of ciprofloxacin. Eur J Clin. Microbiol 1984; 3:339–343
    [Google Scholar]
  11. Lewin C S., Howard B M., A, Ratcliffe N T., Smith J T. 4-quinolones and the SOS response. J Med Microbiol 1989; 29:139–144
    [Google Scholar]
  12. Lewin C S., Smith J T. Bactericidal mechanisms of ofloxacin. J Antimicrob Chemother 1988; 22: Suppl C 1–8
    [Google Scholar]
  13. Bergan T. Pharmacokinetics of fluorinated quinolones. In Andriole V T. ed The quinolones. London, Academic Press; 198823–82
    [Google Scholar]
  14. Weidekamm E., Portmann R., Partos C., Dell D. Single and multiple dose pharmacokinetics of fleroxacin. J Antimicrob Chemother 1988; 22: Suppl D 145–154
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-32-2-83
Loading
/content/journal/jmm/10.1099/00222615-32-2-83
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error