RT Journal Article SR Electronic(1) A1 Lewin, C. S. A1 Amyes, S. G. B.YR 1990 T1 Conditions Required for the Bactericidal Activity of Fleroxacin and Pefloxacin Against Escherichia Coli KL 16 JF Journal of Medical Microbiology, VO 32 IS 2 SP 83 OP 86 DO https://doi.org/10.1099/00222615-32-2-83 PB Microbiology Society, SN 1473-5644, AB Summary Pefloxacin and fleroxacin showed biphasic bactericidal activity against Escherichia coli KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, an inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxacin and fleroxacin were also active against non-dividing E. coli KL16. There fore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-32-2-83