A/J and BALB/c mice differ genetically in their resistance to the facultative intracellular bacterium . We compared the responses of these strains of mice to a virulent infection. BALB/c mice mobilised more peritoneal exudate cells in response to the infection than did A/J mice 30 h after infection, but the increase in bacterial counts in the livers and spleens of BALB/c mice was 10-fold higher than in A/J mice. The response to Concanavalin A (Con A) of spleen cells from BALB/c mice was depressed, and both L3T4 and Lyt-2 T cell subpopulations were decreased following the infection, whereas the response to Con A of A/J mice was increased and the T cell subpopulations were not altered significantly. These results suggest that A/J mice respond more actively to infection than do BALB/c mice, and this may be related to the natural resistance of mice.


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