RT Journal Article SR Electronic(1) A1 TAKAHASHI, M. A1 USHIJIMA, T. A1 SETO, A.YR 1990 T1 Comparison of host responses induced by Salmonella typhimurium infection in genetically resistant and susceptible mice JF Journal of Medical Microbiology, VO 31 IS 3 SP 191 OP 194 DO https://doi.org/10.1099/00222615-31-3-191 PB Microbiology Society, SN 1473-5644, AB Summary A/J and BALB/c mice differ genetically in their resistance to the facultative intracellular bacterium Salmonella typhimurium. We compared the responses of these strains of mice to a virulent S. typhimurium infection. BALB/c mice mobilised more peritoneal exudate cells in response to the infection than did A/J mice 30 h after infection, but the increase in bacterial counts in the livers and spleens of BALB/c mice was 10-fold higher than in A/J mice. The response to Concanavalin A (Con A) of spleen cells from BALB/c mice was depressed, and both L3T4+ and Lyt-2+ T cell subpopulations were decreased following the infection, whereas the response to Con A of A/J mice was increased and the T cell subpopulations were not altered significantly. These results suggest that A/J mice respond more actively to S. typhimurium infection than do BALB/c mice, and this may be related to the natural resistance of mice., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-31-3-191