Skip to content
1887

Abstract

Summary.

Evidence is presented that the high susceptibility of armadillos to infection with cannot be explained solely in terms of body temperature because mutant mice maintained with a body temperature similar to that of armadillos do not become heavily infected with . . The depression of cell-mediated immunity accompanying the low body temperature is not sufficient to produce an overwhelming infection. The results obtained with . suggest that whereas lack of cell-mediated immunity or a low body temperature result in a moderately enhanced infection in the mouse a combination of both of these factors is required to produce an overwhelming infection involving the internal organs.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-14-4-493
1981-11-01
2025-12-11

Metrics

Loading full text...

Full text loading...

References

  1. Burns T. A., Waldrip E. B. 1971; Body temperature and electrocardiographic data for the nine-banded armadillo (Dasypus novemcinctus). J.Mammal 52:472
    [Google Scholar]
  2. Brand P. W. 1959; Temperature variation and leprosy deformity. Int.J. Lepr. 27:1
    [Google Scholar]
  3. Colston M. J., Hilson G. R. F. 1976; Growth of Mycobacterium leprae and M.marinum in congenitally athymic (nude) mice. Nature, Lond 262:399
    [Google Scholar]
  4. Fieldsteel A. H., McIntosh A. H. 1971; Effect of neonatal thymectomy and antithymocytic serum on susceptibility of rats to Mycobacterium leprae infection.. Proc.Soc.exp.Biol.Med 138:408
    [Google Scholar]
  5. Holmes I. B., Hilson G. R. F. 1972; The effect of rifampicin and dapsone on experimental Mycobacterium leprae infections: minimum inhibitory concentrations and bactericidal action. J.med. Microbiol 5:251
    [Google Scholar]
  6. Ingalls A. M., Dickie M. M., Snell G. D. 1950; Obese, new mutation in the house mouse. J. Hered 41:317
    [Google Scholar]
  7. Johansen K. 1961; Temperature regulation in the nine-banded armadillo (Dasypus novemcinctus mexicanus). Physiol. Zool 34:126
    [Google Scholar]
  8. Joosten H. F. P., Van der Kroon P. H. W. 1974; Role of the thyroid in the development of the obese-hyperglycemic syndrome in mice (ob/ob). Metabolism 23:425
    [Google Scholar]
  9. Kirchheimer W. F., Storrs E. E. 1972; Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study of leprosy. 1. Report of lepromatoid leprosy in an experimentally infected armadillo.. Int. Lepr. 39:229
    [Google Scholar]
  10. Kirchheimer W. F., Storrs E. E., Binford C. H. 1971; Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study of leprosy. II. Histopathologic and bacteriologic post-mortem findings in lepromatoid leprosy in the armadillo. Int.Lepr 40:3
    [Google Scholar]
  11. Kohsaka K., Mori T., Ito T. 1976; Lepromatoid lesion developed in the nude mouse inoculated with Mycobacterium leprae. Animal transmission of leprosy.. La Lepro 45:177
    [Google Scholar]
  12. Linell F., Norden A. 1954; Mycobacterium balnei; new acid-fast bacillus occurring in swimming pools and capable of producing skin lesions in humans. Acta tuberc. scand33
    [Google Scholar]
  13. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood.. J.Hyg.,Camb 38:732
    [Google Scholar]
  14. Ng H., Jacobsen P. L., Levy L. 1973; Analogy of Mycobacterium marinum disease to Mycobacterium leprae infection in footpads of mice. Infect.Immun 8:860
    [Google Scholar]
  15. Ohtake M., Bray G. A., Azukizawa M. 1977; Studies on hypothermia and thyroid function in the obese (ob/ob) mouse. Am.Physiol 233:110
    [Google Scholar]
  16. Purtilo D. T., Walsh G. P., Storrs E. E., Banks I. S. 1974; Impact of cool temperatures on transformation of human and armadillo lymphocytes (Dasypus novemcinctus Linn) as related to leprosy. Nature ,Lond 248:450
    [Google Scholar]
  17. Purtilo D. T., Walsh G. P., Storrs E. E., Banks I. S. 1974; Impact of cool temperatures on transformation of human and armadillo lymphocytes (Dasypus novemcinctus Linn). Anat. Rec. 181:725
    [Google Scholar]
  18. Purtilo D. T., Walsh G. P., Storrs E. E., Gannon C. 1975; The immune system of the nine-banded armadillo (Dasypus novemcinctus Linn). Anat. Rec 181:725
    [Google Scholar]
  19. Rees R. J. W. 1965; Recent bacteriologie, immunologie, and pathologic studies on experimental human leprosy in the mouse footpad. Int.J.Lepr 33:646
    [Google Scholar]
  20. Rees R. J. W. 1966; Enhanced susceptibility of thymectomized and irradiated mice to infection with Mycobacterium leprae. Nature,Lond 211:657
    [Google Scholar]
  21. Shepard C. C. 1960a; The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. J.exp.Med 112:445
    [Google Scholar]
  22. Shepard C. C. 1960a; Acid-fast bacilli in nasal excretions in leprosy and results of inoculation mice. Am.J.Hyg 71:147
    [Google Scholar]
  23. Shepard C. C. 1965; Stability of Mycobacterium leprae and temperature optimum for growth. Int.J.Lepr 33:541
    [Google Scholar]
  24. Shepard C. C., McRae D. H. 1968; A new method for counting acid-fast bacteria. int.J. Lepr 36:78
    [Google Scholar]
  25. Storrs E. E. 1971; The nine-banded armadillo: a model for leprosy and other biomedicai research. Int.J.Lepr 39:703
    [Google Scholar]
  26. Storrs E.E., Walsh G. P., Burchfield H. P., Binford C. H. 1974; Leprosy in the armadillo: new model for biomedicai research. Science, N.Y. 183:851
    [Google Scholar]
  27. Wislocki G. B., Enders R. K. 1935; Body temperatures of sloths, anteaters and armadillos. Mammol 16:328
    [Google Scholar]
  28. Yen T. T., Fuller R. W., Pearson D. V. 1974; The response of obese (ob/ob) and diabetic (db/db) mice to treatments that influence body temperature. Comp.Biochem.Physiol 49A:377
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-14-4-493
Loading
/content/journal/jmm/10.1099/00222615-14-4-493
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An error occurred
Approval was partially successful, following selected items could not be processed due to error