1887

Abstract

Summary

Native staphylococcal δ haemolysin was poorly immunogenic in the mouse. After treatment with formaldehyde at H 5 or H 7·5, haemolytic activity was rapidly lost but antigenic reactivity retained and, at H 5, im-munogenicity was enhanced. Treatment of the haemolysin with formaldehyde at H 9·5 reduced haemolytic activity by 97% but did not enhance immunogenicity. There was no evidence of polymerisation of formaldehyde-treated δ haemolysin, and the enhanced immunogenicity was considered to be partly due to a reduced affinity for phospholipids.

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/content/journal/jmm/10.1099/00222615-13-2-223
1980-05-01
2019-12-15
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-13-2-223
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