1887

Abstract

Summary

Native staphylococcal δ haemolysin was poorly immunogenic in the mouse. After treatment with formaldehyde at H 5 or H 7.5, haemolytic activity was rapidly lost but antigenic reactivity retained and, at H 5, im-munogenicity was enhanced. Treatment of the haemolysin with formaldehyde at H 9.5 reduced haemolytic activity by 97% but did not enhance immunogenicity. There was no evidence of polymerisation of formaldehyde-treated δ haemolysin, and the enhanced immunogenicity was considered to be partly due to a reduced affinity for phospholipids.

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1980-05-01
2021-10-26
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