1887

Abstract

SUMMARY

Forty-one faecal samples from infectious-hepatitis patients and their contacts were investigated for the presence of hepatitis-A-associated viral particles. Of these, 16 gave a positive result by immune electronmicroscopy or caesium-chloride density-gradient centrifugation. The latter method proved invaluable in detecting small numbers of virus particles. The particles found had a buoyant density of 1.34−1.35 and a size range of 21-28 nm. Epidemio-logical evidence suggested that they might be the causative agent of hepatitis A.

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/content/journal/jmm/10.1099/00222615-10-1-43
1977-02-01
2024-12-07
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References

  1. Almeida J. D., Gay F. W., Wreghitt G. 1974; Pitfalls in the study of hepatitis A. Lancet 2:748
    [Google Scholar]
  2. Bradley D. W., Hornbeck C. L., Gravelle C. R., Cook E. H., Maynard J. E. 1975; CsCl banding of hepatitis A associated virus-like particles. J. infect. Dis 131:304
    [Google Scholar]
  3. Dienstag J. L., Feinstone S. M., Kapikian A. Z., Purcell R. H. 1975; Faecal shedding of hepatitis-A antigen. Lancet 1:765
    [Google Scholar]
  4. Feinstone S. M., Kapikian A. Z., Purcell R. H. 1973; Hepatitis A: detection by immune electron microscopy of a virus-like antigen associated with acute illness. Science, N. Y 182:1026
    [Google Scholar]
  5. Feinstone S. M., Kapikian A. Z., Gerin J. L., Purcell R. H. 1974; Buoyant density of the hepatitis-A virus-like particles in cesium chloride. J. Virol 13:1412
    [Google Scholar]
  6. Gravelle C. R., Hornbeck C. L., Maynard J. E., Schable C. A., Cooke E. H., Bradley D. W. 1975; Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. J. infect. Dis 131:167
    [Google Scholar]
  7. Krugman S., Ward R., Giles J. P., Bodansky O., Jacobs A. M. 1959; Infectious hepatitis: detection of virus during the incubation period and in clinically inapparent infection. New Engl. J. Med 261:729
    [Google Scholar]
  8. Leger R. T., Boyer K. M., Pattison C. P., Maynard J. E. 1975; Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. I. Epidemiologic studies. J. infect. Dis 131:163
    [Google Scholar]
  9. Provost P. J., Ittensohn O. L., Villarejos V. M., Arguedas J. A., Hilleman M. R. 1973; Etiologic relationship of marmoset-propagated CR326 hepatitis A virus to hepatitis in man. Proc. Soc. exp. Biol. Med 142:1257
    [Google Scholar]
  10. Provost P. J., Wolanski B. S., Miller W. J., Ittensohn O. L., McAleer W. J., Hilleman M. R. 1975; Physical, chemical and morphological dimensions of human hepatitis A virus strain CR326 (38578). Proc. Soc. exp. Biol. Med 148:532
    [Google Scholar]
  11. Thornton A., Zuckerman A. J., Almeida J. D. 1975; Chimpanzee model hepatitis-A virus. Lancet 2:226
    [Google Scholar]
  12. Ward R., Krugman S., Giles J. P., Jacobs A. M., Bodansky O. 1958; Infectious hepatitis: Studies of its natural history and prevention. New Engl. J. Med 258:407
    [Google Scholar]
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