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1887

Journal of General Virology header logo Journal of General Virology

Volume 88, Issue 9

Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances infection of CD4 T lymphocytes No Access

Abstract

Previous studies have identified several host-derived cell-surface proteins incorporated within emerging human immunodeficiency virus type 1 (HIV-1) particles. Some of these molecules play a role in different steps of the virus life cycle and are often advantageous for the virus. We report here that the leukocyte L-selectin (also called CD62L) remains functional when inserted within the envelope of HIV-1. Indeed, we demonstrate that adsorption of virions to endothelial cells is enhanced upon acquisition of host-derived CD62L. The more important binding of CD62L-bearing HIV-1 particles resulted in a more efficient virus transmission to CD4 T lymphocytes. Capture and eventual transfer of such CD62L-bearing virions by the endothelium could play a role in the pathogenesis of HIV-1 infection.

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/content/journal/jgv/10.1099/vir.0.83032-0
2007-09-01
2025-03-24
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Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes
J. Gen. Virol. 88, 2568 (2007); https://doi.org/10.1099/vir.0.83032-0
/content/journal/jgv/10.1099/vir.0.83032-0
/content/journal/jgv/10.1099/vir.0.83032-0
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