@article{mbs:/content/journal/jgv/10.1099/vir.0.83032-0, author = "Thibault, Sandra and Tardif, Mélanie R. and Gilbert, Caroline and Tremblay, Michel J.", title = "Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes", journal= "Journal of General Virology", year = "2007", volume = "88", number = "9", pages = "2568-2573", doi = "https://doi.org/10.1099/vir.0.83032-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83032-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Previous studies have identified several host-derived cell-surface proteins incorporated within emerging human immunodeficiency virus type 1 (HIV-1) particles. Some of these molecules play a role in different steps of the virus life cycle and are often advantageous for the virus. We report here that the leukocyte L-selectin (also called CD62L) remains functional when inserted within the envelope of HIV-1. Indeed, we demonstrate that adsorption of virions to endothelial cells is enhanced upon acquisition of host-derived CD62L. The more important binding of CD62L-bearing HIV-1 particles resulted in a more efficient virus transmission to CD4+ T lymphocytes. Capture and eventual transfer of such CD62L-bearing virions by the endothelium could play a role in the pathogenesis of HIV-1 infection.", }