1887

Abstract

Human T-cell leukaemia virus type-1 (HTLV-1) infection causes adult T-cell leukaemia (ATL). The viral protein HTLV-1 bZIP factor (HBZ) is constitutively expressed in ATL cells, suggesting that HBZ plays a major role in the pathogenesis of HTLV-1-associated disease. Here, we identified centromere protein B (CENP-B) as a novel interacting partner of HBZ. HBZ and CENP-B associate with their central regions in cells. Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.070201-0
2015-01-01
2020-09-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/96/1/159.html?itemId=/content/journal/jgv/10.1099/vir.0.070201-0&mimeType=html&fmt=ahah

References

  1. Gaudray G., Gachon F., Basbous J., Biard-Piechaczyk M., Devaux C., Mesnard J. M. 2002; The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 76:12813–12822 [CrossRef][PubMed]
    [Google Scholar]
  2. Hasegawa H., Sawa H., Lewis M. J., Orba Y., Sheehy N., Yamamoto Y., Ichinohe T., Tsunetsugu-Yokota Y., Katano H.other authors 2006; Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12:466–472 [CrossRef][PubMed]
    [Google Scholar]
  3. Hudson D. F., Fowler K. J., Earle E., Saffery R., Kalitsis P., Trowell H., Hill J., Wreford N. G., de Kretser D. M.other authors 1998; Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights. J Cell Biol 141:309–319 [CrossRef][PubMed]
    [Google Scholar]
  4. Kapoor M., Montes de Oca Luna R., Liu G., Lozano G., Cummings C., Mancini M., Ouspenski I., Brinkley B. R., May G. S. 1998; The cenpB is not essential in mice. Chromosoma 107:570–576 [CrossRef][PubMed]
    [Google Scholar]
  5. Kitagawa K., Masumoto H., Ikeda M., Okazaki T. 1995; Analysis of protein-DNA and protein-protein interactions of centromere protein B (CENP-B) and properties of the DNA-CENP-B complex in the cell cycle. Mol Cell Biol 15:1602–1612[PubMed]
    [Google Scholar]
  6. Mukai R., Ohshima T. 2014; HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm. Oncogene 33:2317–2328 [CrossRef][PubMed]
    [Google Scholar]
  7. Murata K., Hayashibara T., Sugahara K., Uemura A., Yamaguchi T., Harasawa H., Hasegawa H., Tsuruda K., Okazaki T.other authors 2006; A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J Virol 80:2495–2505 [CrossRef][PubMed]
    [Google Scholar]
  8. Nakano M., Okamoto Y., Ohzeki J., Masumoto H. 2003; Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes. J Cell Sci 116:4021–4034 [CrossRef][PubMed]
    [Google Scholar]
  9. Nguyen C. T., Weisenberger D. J., Velicescu M., Gonzales F. A., Lin J. C., Liang G., Jones P. A. 2002; Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res 62:6456–6461[PubMed]
    [Google Scholar]
  10. Ohshima T., Mukai R., Nakahara N., Matsumoto J., Isono O., Kobayashi Y., Takahashi S., Shimotohno K. 2010; HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element. J Cell Biochem 111:187–194 [CrossRef][PubMed]
    [Google Scholar]
  11. Ohsugi T., Wakamiya M., Morikawa S., Matsuura K., Kumar J. M., Kumasaka T., Yamaguchi K. 2013; Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. Oncol Res 20:403–410 [CrossRef][PubMed]
    [Google Scholar]
  12. Okada T., Ohzeki J., Nakano M., Yoda K., Brinkley W. R., Larionov V., Masumoto H. 2007; CENP-B controls centromere formation depending on the chromatin context. Cell 131:1287–1300 [CrossRef][PubMed]
    [Google Scholar]
  13. Park Y. S., Jin M. Y., Kim Y. J., Yook J. H., Kim B. S., Jang S. J. 2008; The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma. Ann Surg Oncol 15:1968–1976 [CrossRef][PubMed]
    [Google Scholar]
  14. Perez-Castro A. V., Shamanski F. L., Meneses J. J., Lovato T. L., Vogel K. G., Moyzis R. K., Pedersen R. 1998; Centromeric protein B null mice are viable with no apparent abnormalities. Dev Biol 201:135–143 [CrossRef][PubMed]
    [Google Scholar]
  15. Satou Y., Yasunaga J., Yoshida M., Matsuoka M. 2006; HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A 103:720–725 [CrossRef][PubMed]
    [Google Scholar]
  16. Simonis N., Rual J. F., Lemmens I., Boxus M., Hirozane-Kishikawa T., Gatot J. S., Dricot A., Hao T., Vertommen D.other authors 2012; Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology 9:26 [CrossRef][PubMed]
    [Google Scholar]
  17. Takeda S., Maeda M., Morikawa S., Taniguchi Y., Yasunaga J., Nosaka K., Tanaka Y., Matsuoka M. 2004; Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer 109:559–567 [CrossRef][PubMed]
    [Google Scholar]
  18. Tamiya S., Matsuoka M., Etoh K., Watanabe T., Kamihira S., Yamaguchi K., Takatsuki K. 1996; Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 88:3065–3073[PubMed]
    [Google Scholar]
  19. Tanaka Y., Kurumizaka H., Yokoyama S. 2005; CpG methylation of the CENP-B box reduces human CENP-B binding. FEBS J 272:282–289 [CrossRef][PubMed]
    [Google Scholar]
  20. Tanaka H., Nishioka Y., Yokoyama Y., Higashiyama S., Matsuura N., Matsuura S., Hieda M. 2012; Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner. Biochem Biophys Res Commun 420:721–726 [CrossRef][PubMed]
    [Google Scholar]
  21. Taniguchi Y., Nosaka K., Yasunaga J., Maeda M., Mueller N., Okayama A., Matsuoka M. 2005; Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology 2:64 [CrossRef][PubMed]
    [Google Scholar]
  22. Uchiyama T. 1997; Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol 15:15–37 [CrossRef][PubMed]
    [Google Scholar]
  23. Yasunaga J., Matsuoka M. 2011; Molecular mechanisms of HTLV-1 infection and pathogenesis. Int J Hematol 94:435–442 [CrossRef][PubMed]
    [Google Scholar]
  24. Yoshida M. 2001; Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol 19:475–496 [CrossRef][PubMed]
    [Google Scholar]
  25. Yoshida M. 2005; Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 24:5931–5937 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.070201-0
Loading
/content/journal/jgv/10.1099/vir.0.070201-0
Loading

Data & Media loading...

Supplements

Supplementary Data

PDF

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error