%0 Journal Article %A Mukai, Risa %A Ohshima, Takayuki %T HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B %D 2015 %J Journal of General Virology, %V 96 %N 1 %P 159-164 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.070201-0 %I Microbiology Society, %X Human T-cell leukaemia virus type-1 (HTLV-1) infection causes adult T-cell leukaemia (ATL). The viral protein HTLV-1 bZIP factor (HBZ) is constitutively expressed in ATL cells, suggesting that HBZ plays a major role in the pathogenesis of HTLV-1-associated disease. Here, we identified centromere protein B (CENP-B) as a novel interacting partner of HBZ. HBZ and CENP-B associate with their central regions in cells. Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.070201-0