1887

Abstract

SUMMARY

Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.

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/content/journal/jgv/10.1099/0022-1317-70-6-1605
1989-06-01
2022-08-15
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References

  1. Barrett A. D. T., Gould E. A. 1986; Antibody-mediated early death in vivo after inspection with yellow fever virus. Journal of General Virology 67:2539–2542
    [Google Scholar]
  2. Berge T. O., Gleiser C. E. G., Gochenour W. S., Miesse M. L., Tigertt W. D. 1961; Studies on the virus of Venezuelan equine encephalomyelitis: II. Modification by specific immune serum of response of central nervous system of mice. Journal of Immunology 87:509–517
    [Google Scholar]
  3. Blancou J., Andral B., Andral L. 1980; A model in mice for the study of the early death phenomenon after vaccination and challenge with rabies virus. Journal of General Virology 50:433–435
    [Google Scholar]
  4. Gould E. A., Buckley A., Cammack N., Barrett A. D. T., Clegg J. C. S., Ishak R., Varma M. G. R. 1985; Examination of the immunological relationships between flaviviruses using yellow fever virus monoclonal antibodies. Journal of General Virology 66:1369–1382
    [Google Scholar]
  5. Gould E. A., Buckley A., Barrett A. D. T., Cammack N. 1986; Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice. Journal of General Virology 67:591–595
    [Google Scholar]
  6. Gould E. A., Buckley A., Groeger B. K., Cane P. A., Doenhoff M. 1987; Immune enhancement of yellow fever virus neurovirulence for mice: studies of mechanisms involved. Journal of General Virology 68:3105–3112
    [Google Scholar]
  7. Halstead S. B., Shotwell H., Casals J. 1973; Studies of the pathogenesis of dengue infection in monkeys. II. Clinical laboratory responses to heterologous infection. Journal of Infectious Diseases 128:15–22
    [Google Scholar]
  8. Henchal E. A., Henchal L. S., Schlesinger J. J. 1988; Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus. Journal of General Virology 69:2101–2107
    [Google Scholar]
  9. Porterfield J. S. 1980; Antigenic characteristics and classification of Togaviridae. In The Togaviruses13–46 Schlesinger R. W. New York & London: Academic Press;
    [Google Scholar]
  10. Prabhakar B. S., Nathanson N. 1981; Acute rabies death mediated by antibody. Nature, London 290:590–591
    [Google Scholar]
  11. Scott R. MCN., Eckels K. H., Bancroft W. H., Summers P. L., Mccown J. M., Anderson J. H., Rumell P. K. 1983; Dengue 2 vaccine: dose response in volunteers in relation to yellow fever immune status. Journal of Infectious Diseases 148:1055–1060
    [Google Scholar]
  12. Sikes R. K., Cleary W. F., Koprowski H., Wiktor T. J., Kaplan M. M. 1971; Effective protection of monkeys against death from street rabies by post-exposure administration of tissue culture rabies vaccine. Bulletin of the World Health Organization 45:1–11
    [Google Scholar]
  13. Webb H. E., Wight D. G. D., Platt G. S., Smith C. E. G. 1968; Langat virus encephalitis in mice. I. The effect of the administration of specific antiserum. Journal of Hygiene 66:343–354
    [Google Scholar]
  14. Weiss R. C., Scott F. W. 1981; Antibody mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue haemorhagic fever. Comparative Immunology, Microbiology and Infectious Disease 4:175–289
    [Google Scholar]
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