RT Journal Article SR Electronic(1) A1 Gould, E. A. A1 Buckley, A.YR 1989 T1 Antibody-dependent Enhancement of Yellow Fever and Japanese Encephalitis Virus Neurovirulence JF Journal of General Virology, VO 70 IS 6 SP 1605 OP 1608 DO https://doi.org/10.1099/0022-1317-70-6-1605 PB Microbiology Society, SN 1465-2099, AB SUMMARY Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-6-1605