@article{mbs:/content/journal/jgv/10.1099/0022-1317-70-6-1605, author = "Gould, E. A. and Buckley, A.", title = "Antibody-dependent Enhancement of Yellow Fever and Japanese Encephalitis Virus Neurovirulence", journal= "Journal of General Virology", year = "1989", volume = "70", number = "6", pages = "1605-1608", doi = "https://doi.org/10.1099/0022-1317-70-6-1605", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-6-1605", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "yellow fever", keywords = "Japanese encephalitis", keywords = "immune enhancement", abstract = "SUMMARY Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.", }