1887

Abstract

SUMMARY

Factors in normal serum which enhance Semliki Forest virus neutralization by specific immune guinea-pig serum have been demonstrated in a range of normal domestic and laboratory animals. The factors alfecting the assay system for accessory factors have been determined and enhancement of neutralization by normal guinea-pig serum in other virus/cell systems has been demonstrated. Accessory factors are denatured by various physical and chemical procedures but survive freeze-drying. The effect of ageing on accessory factors in normal and germ-free rats and rabbits and in normal calves, lambs, guinea-pigs and mice revealed marked species differences but showed no difference between normal and germ-free animals of the same species. There was no correlation between haemolytic complement and accessory factor levels present in a serum, except in rats, although the two complexes had several properties in common.

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1970-06-01
2022-01-28
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References

  1. Capstick P. B., Telling R. C., Chapman W. G., Stewart D. L. 1962; Growth of a cloned strain of hamster kidney cells in suspended cultures and their susceptibility to the virus of foot-and-mouth disease. Nature; London: 1951163
    [Google Scholar]
  2. Clarke D. H., Casals J. 1958; Techniques for haemagglutination and haemagglutination-inhibition with arthropod-borne viruses. American Journal of Tropical Medicine and Hygiene 7:561
    [Google Scholar]
  3. Dulbecco R. 1952; Production of plaques in monolayer tissue cultures by single particles of an animal virus. Proceedings of the National Academy of Sciences of the United States of America 38:747
    [Google Scholar]
  4. Johnson H. N. 1963; Selection of a variant of Western encephalitis virus of low pathogenicity for study as a live virus vaccine. American Journal of Tropical Medicine and Hygiene 12:604
    [Google Scholar]
  5. Kabat E. A., Mayer M. M. 1961 Experimental Immunochemistry, 2nd ed. p 162 Springfield, Illinois: Thomas;
    [Google Scholar]
  6. Macpherson L. A., Stoker M. G. P. 1962; Polyoma transformation of hamster cell clones-an investigation of genetic factors affecting cell competence. Virology 16:147
    [Google Scholar]
  7. Mueller J. H. 1931; The effect of Alexin in virus-antivirus mixtures. Journal of Immunology 20:17
    [Google Scholar]
  8. Porterfield j. s. 1960; A simple plaque-inhibition test for the study of arboviruses. Bulletin of the World Health Organization 22:373
    [Google Scholar]
  9. Shuratov I. KH., Yabrov A. A., Smorodintsev A. A. 1967; Relationship between the contents of virus neutralising inhibitors and cofactor in the blood and the course of experimental vaccinia infection in rabbits. Acta virologica 11:485
    [Google Scholar]
  10. Shuratov I. KH., Smorodintsev A. A., Yabrov A. A. 1967; Study of the protective role of cofactor in a model of intradermal vaccinia infection in immunised rabbits. Voprosy virusologii 12:224
    [Google Scholar]
  11. Smorodintsev A. A., Yabrov A. A. 1963a; Intensity of the interaction of antibody and virus in the haemagglutination inhibition test in the presence of non-specific thermolabile stimulator of antibody. Acta virologica 7:138
    [Google Scholar]
  12. Smorodintsev A. A., Yabrov A. A. 1963b; The mechanism of enhanced activity of anti-influenza virus neutralising antisera on their interaction with native serum from normal animals. Acta virologica 7:193
    [Google Scholar]
  13. Styk B., Hana L., Franek F., Sokol F., Mensik J. 1962a; Investigations on cofactor and influenza antibodies by density gradient zonal centrifugation. Acta virologica 6:478
    [Google Scholar]
  14. Styk B., Hana L., Franek F., Sokol F., Mensik K. 1963; Cofactor and specific antibodies against influenza viruses. VII. The nature of cofactor and influenza antibodies studied by density gradient zonal centrifugation. Acta virologica 7:25
    [Google Scholar]
  15. Styk B., Hana L., Rathova V., Kociskova D. 1965; Investigations of the complement components and the ‘antibody cofactor’ by gel filtration on Sephadex G-200. Science Tools 12:37
    [Google Scholar]
  16. Styk B., Kociskova D., Hana L. 1964; Cofactor and specific anti-bodies against influenza viruses. VIII. On the different nature of ‘antibody cofactor’ and complement. Acta virologica 8:496
    [Google Scholar]
  17. Styk B., Mensik D., Sterzl J., Hana L., Borecky L. 1962b; Cofactor and specific antibodies against influenza viruses. VI. The relationship of cofactor to the so-called natural antibodies as revealed by a study of sera from newborn piglets. Acta virologica 6:519
    [Google Scholar]
  18. Tikasingh E. S., Spence L., Downs W. G. 1966; The use of adjuvant and sarcoma 180 cells in the production of mouse hyperimmune ascitic fluids to arboviruses. American Journal of Tropical Medicine and Hygiene 15:219
    [Google Scholar]
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