1887

Abstract

Summary

Factors in normal serum which enhance Semliki Forest virus neutralization by specific immune guinea-pig serum have been demonstrated in a range of normal domestic and laboratory animals. The factors affecting the assay system for accessory factors have been determined and enhancement of neutralization by normal guinea-pig serum in other virus/cell systems has been demonstrated. Accessory factors are denatured by various physical and chemical procedures but survive freeze-drying. The effect of ageing on accessory factors in normal and germ-free rats and rabbits and in normal calves, lambs, guinea-pigs and mice revealed marked species differences but showed no difference between normal and germ-free animals of the same species. There was no correlation between haemolytic complement and accessory factor levels present in a serum, except in rats, although the two complexes had several properties in common.

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/content/journal/jgv/10.1099/0022-1317-7-3-211
1970-06-01
2019-11-12
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-7-3-211
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