1887

Abstract

SUMMARY

Subcutaneous injection of microgram quantities of purified SV40 DNA into newborn Syrian hamsters induced sarcomas. The tumour cells contained SV40 T-antigen and virus could be rescued from the cultured tumour cells. Addition of poly-L-ornithine or calf thymus DNA to the injection mixture did not enhance the tumour incidence. SV40 DNA cleaved with endonuclease EcoRI also displayed oncogenic potential.

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/content/journal/jgv/10.1099/0022-1317-37-3-635
1977-12-01
2022-07-04
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