1887

Abstract

SUMMARY

Additional antigenic sites, distinct from those present on spherical 20 nm diam. particles of hepatitis B surface antigen (HBAg), are exposed on the surface of Dane particles and tubular forms of HBAg. The immunological relationship of these sites to e-antigen, an antigen detected earlier in HBAg-positive sera from patients with chronic hepatitis, cirrhosis or acute hepatitis but not in healthy HBAg-carriers, was established by immune electron microscopy and affinity chromatography. These findings suggest that e-antigen may be potentially useful in active immunization against hepatitis B.

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1976-03-01
2022-12-08
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