%0 Journal Article %A Neurath, A. R. %A Trepo, C. %A Chen, M. %A Prince, A. M. %T Identification of Additional Antigenic Sites on Dane Particles and the Tubular Forms of Hepatitis B Surface Antigen %D 1976 %J Journal of General Virology, %V 30 %N 3 %P 277-285 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-30-3-277 %I Microbiology Society, %X SUMMARY Additional antigenic sites, distinct from those present on spherical 20 nm diam. particles of hepatitis B surface antigen (HBsAg), are exposed on the surface of Dane particles and tubular forms of HBsAg. The immunological relationship of these sites to e-antigen, an antigen detected earlier in HBsAg-positive sera from patients with chronic hepatitis, cirrhosis or acute hepatitis but not in healthy HBsAg-carriers, was established by immune electron microscopy and affinity chromatography. These findings suggest that e-antigen may be potentially useful in active immunization against hepatitis B. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-30-3-277