1887

Abstract

To the best of our knowledge, we report the first infection in a native hip joint with subsequent prosthetic joint infection in a patient at a state of hypogammaglobulinemia. The infection developed following chemotherapy for B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). After chemotherapy, hip arthroplasty was performed for destructive septic arthritis. However, infection in the hip persisted with several failing revisions for more than 3 years, until ultimately hypogammaglobulinemia and T-/B-lymphocytopenia were diagnosed, and supplementation with i.v. immunoglobulins was able to achieve infection control.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
Loading

Article metrics loading...

/content/journal/acmi/10.1099/acmi.0.000233
2021-05-10
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/acmi/3/5/acmi000233.html?itemId=/content/journal/acmi/10.1099/acmi.0.000233&mimeType=html&fmt=ahah

References

  1. Czepiel J, Dróżdż M, Pituch H. Clostridium difficile infection: review. Eur J Clin Microbiol Infect Dis 2019; 38:1211–1221 [View Article][PubMed]
    [Google Scholar]
  2. Brassinne L, Rodriguez-Villalobos H, Jonckheere S, Dubuc JE, Yombi JC. Early infection of hip joint prosthesis by Clostridium difficile in an HIV-1 infected patient. Anaerobe 2014; 27:96–99 [View Article][PubMed]
    [Google Scholar]
  3. Hill E, Workman AD, Lee F, Hollaway R, Cavuoti D et al. Bacteremia and Septic Arthritis due to a Nontoxigenic Strain of Clostridium difficile in a Patient With Sickle Cell Disease. Open Forum Infect Dis 2018; 5:ofx278ofx278 [View Article][PubMed]
    [Google Scholar]
  4. Gregg KS, Alexander KA. Native joint septic arthritis caused by Clostridium difficile in an 11-year old with hemoglobin SS disease. Pediatr Infect Dis J 2009; 28:853 [View Article][PubMed]
    [Google Scholar]
  5. García-Lechuz JM, Hernangómez S, Juan RS, Peláez T, Alcalá L et al. Extra-intestinal infections caused by Clostridium difficile. Clin Microbiol Infect 2001; 7:453–457 [View Article][PubMed]
    [Google Scholar]
  6. Birnbaum J, Bartlett JG, Gelber AC. Clostridium difficile: an under-recognized cause of reactive arthritis?. Clin Rheumatol 2008; 27:253–255 [View Article][PubMed]
    [Google Scholar]
  7. Al-Tawfiq JA, Babiker MM. Multi-focal clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review. Diagn Microbiol Infect Dis 2020; 96:114915 [View Article][PubMed]
    [Google Scholar]
  8. Duraisingham SS, Buckland M, Dempster J, Lorenzo L, Grigoriadou S et al. Primary vs. Secondary antibody deficiency: Clinical features and infection outcomes of immunoglobulin replacement. PLoS One 2014; 9:e100324 [View Article][PubMed]
    [Google Scholar]
  9. Ameratunga R, Ahn Y, Steele R, Woon ST. The natural history of untreated primary Hypogammaglobulinemia in adults: implications for the diagnosis and treatment of Common Variable Immunodeficiency Disorders (CVID). Front Immunol 2019; 10:1541 [View Article][PubMed]
    [Google Scholar]
  10. Diaz-Ledezma C, Baker J, Parvizi J. “Warning signs” of primary immunodeficiency among patients with periprosthetic joint infection. J Appl Biomater Funct Mater 2014; 12:65–69 [View Article][PubMed]
    [Google Scholar]
  11. Driessen GJ, Dalm VA, van Hagen PM. Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum. Haematologica 2013; 98:1617–1623 [View Article][PubMed]
    [Google Scholar]
  12. Leif Hanitsch PH, Burkhard-Meier U, Wehr C. Therapie primärer Antikörpermangelerkrankungen; 2019 https://www.awmf.org/uploads/tx_szleitlinien/189-001l_S3_Therapie-primaerer-Antikoerpermangelerkrankungen-2019-05_01.pdf
  13. Abad CL, Phuoc V, Kapoor P. Bone and joint infections among hematopoietic stem cell transplant recipients. J Bone Jt Infect 2019; 4:209–215 [View Article][PubMed]
    [Google Scholar]
  14. Thoendel M, Jeraldo P, Greenwood-Quaintance KE. A novel prosthetic joint infection pathogen, Mycoplasma salivarium, identified by metagenomic shotgun sequencing. Clin Infect Dis 2017; 65:332–335 [View Article][PubMed]
    [Google Scholar]
  15. Roerdink RL, Douw CM, Leenders AC. Bilateral periprosthetic joint infection with Ureaplasma urealyticum in an immunocompromised patient. Infection 2016; 44:807–810 [View Article][PubMed]
    [Google Scholar]
  16. Peterson MC, Farr RW, Castiglia M. Prosthetic hip infection and bacteremia due to Campylobacter jejuni in a patient with AIDS. Clin Infect Dis 1993; 16:439–440 [View Article][PubMed]
    [Google Scholar]
  17. Samson M, Audia S, Lakomy D, Bonnotte B, Tavernier C et al. Diagnostic strategy for patients with hypogammaglobulinemia in rheumatology. Joint Bone Spine 2011; 78:241–245 [View Article][PubMed]
    [Google Scholar]
  18. Raje N, Dinakar C. Overview of immunodeficiency disorders. Immunol Allergy Clin North Am 2015; 35:599–623 [View Article][PubMed]
    [Google Scholar]
  19. Whitman CB, Czosnowski QA. Fidaxomicin for the treatment of Clostridium difficile infections. Ann Pharmacother 2012; 46:219–228 [View Article][PubMed]
    [Google Scholar]
  20. Cocanour CS. Best strategies in recurrent or persistent Clostridium difficile infection. Surg Infect (Larchmt) 2011; 12:235–239 [View Article][PubMed]
    [Google Scholar]
  21. Whitman CB, Czosnowski QA. Fidaxomicin for the treatment of Clostridium difficile infections. Ann Pharmacother 2012; 46:219–228 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.0.000233
Loading
/content/journal/acmi/10.1099/acmi.0.000233
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error