1887

Abstract

It has been shown previously that expression of the operon, encoding proteolytic subunits of the Clp complex, the gene, encoding the ATPase subunit, and the gene, encoding another ATP-dependent protease, are all activated by ClgR. The ClgR regulon also includes the gene itself. It is shown here that the degradation of ClgR and Lon is ClpP1/P2-dependent and that the two C-terminal alanines of these new substrates are involved in their stability. The ClpC1 protein, which does not end with two alanines, is also accumulated in a mutant. The results presented here support the idea that ClpP1/P2 ensure post-translational control of ClgR regulon members, including ClgR itself.

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2006-04-01
2019-10-13
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