1887

Abstract

It has been shown that cells with increased expression of the gene encoding exhibit enhanced cell lysis in early stationary phase. Further analysis of the lysis phenomenon was performed using a transient expression system of the gene and by DNA microarray. The former analysis revealed a -directed cell lysis, specific for early stationary phase but not for the exponential phase. The microarray analysis with RNAs from exponential and early stationary phase cells revealed that a large number of genes were up- or down-regulated when the gene was induced, and that several genes were induced in a phase-specific manner. The upregulated genes include many previously identified regulon genes, suggesting that a large number of genes are under the control of in this organism. These genes are involved in various cellular activities, including the cell envelope, cellular processes, regulatory functions, transport and translation. Genes that are presumably related to phase-specific cell lysis in are discussed.

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2005-08-01
2019-10-17
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