1887

Abstract

The regulon is induced by different stresses that most probably affect integrity of the cell envelope. The activity of the extracytoplasmic function (ECF) sigma factor is modulated by the transmembrane anti-sigma factor RsiW, which undergoes stress-induced degradation in a process known as regulated intramembrane proteolysis, finally resulting in the release of and the transcription of -controlled genes. Mutations in the gene, which encodes an ATP binding cassette (ABC) of an ABC transporter of unknown function, block site-2 proteolysis of RsiW by the intramembrane cleaving protease RasP (YluC). In addition, degradation of the cell division protein FtsL, which represents a second RasP substrate, is blocked in an -negative strain. The defect in induction of an -knockout strain could be partly suppressed by overproducing RasP. A -knockout strain displayed the same pleiotropic phenotype as an knockout, namely defects in processing -amylase, in competence development, and in formation of multicellular structures known as biofilms.

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2008-07-01
2019-11-12
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