1887

Abstract

is an opportunistic human pathogen that causes chronic biofilm-based infections in host organisms. employs quorum sensing (QS) to control expression of its virulence, and to establish and maintain chronic infections. Under such conditions, the biofilm mode of growth contributes significantly to tolerance to the action of the innate and adaptive defence system and numerous antibiotics. In the present study, an foreign-body infection model was established in the peritoneal cavity of mice. Experimental data showed that QS-deficient are cleared more rapidly from silicone implants as compared to their wild-type counterparts. Concurrently, treatment with the QS inhibitor furanone C-30 of mice harbouring implants colonized with the wild-type resulted in a significantly faster clearing of the implants as compared to the placebo-treated group. These results were obtained with both an inbred (BALB/c) and an outbred (NMRI) mouse strain. The present results support a model by which functional QS systems play a pivotal role in the ability of bacteria to resist clearing by the innate immune system and strongly suggest that the efficiency of the mouse innate defence against biofilm-forming is improved when the bacteria are treated with QS drugs that induce QS deficiency.

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2007-07-01
2019-11-19
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