1887

Abstract

Dps, the most abundant protein during the stationary growth phase, in is required for resistance to reactive oxygen species produced by the host during infection. It has been reported that in expression is controlled by RpoS and Fur proteins. However, the regulation and function of Dps remain to be resolved. In the present work we demonstrate that activation of the complex RcsCDB regulatory system increases expression during exponential growth of . In addition, we show that such upregulation produces high levels of HO resistance. This phenotype allows the bacteria to avoid reactive oxygen species killing at early stages of growth, thus protecting its genetic material.

Funding
This study was supported by the:
  • CONICET (Award PIP 2518)
  • CIUNT (Award 26/D439)
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2014-10-01
2021-07-26
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