1887

Abstract

The population structure of the species was investigated by multilocus variable number of tandem repeats (VNTR) analysis (MLVA) and sequencing of three VNTRs (Lpms01, Lpms04 and Lpms13) in selected strains. Of 150 isolates of diverse origins, 136 (86 %) were distributed into eight large MLVA clonal complexes (VACCs) and the rest were either unique or formed small clusters of up to two MLVA genotypes. In spite of the lower degree of genome-wide linkage disequilibrium of the MLVA loci compared with sequence-based typing, the clustering achieved by the two methods was highly congruent. The detailed analysis of VNTR Lpms04 alleles showed a very complex organization, with five different repeat unit lengths and a high level of internal variation. Within each MLVA-defined VACC, Lpms04 was endowed with a common recognizable pattern with some interesting exceptions. Evidence of recombination events was suggested by analysis of internal repeat variations at the two additional VNTR loci, Lpms01 and Lpms13. Sequence analysis of VNTR locus Lpms04 alone provides a first-line assay for allocation of a new isolate within the population structure and for epidemiological studies.

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2011-09-01
2019-12-07
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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

PDF

Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

PDF

Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

PDF

Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

PDF

Characteristics of so far untyped strains that have been analysed by MLVA-8 in this study [PDF](110 kb) MVLA data from 150 isolates and VACC assignment [PDF](464 kb) Clustering analysis of the 150 isolates genotyped by MLVA-8. STs are shown for comparison when available. Clusters of four or more genotypes are marked with coloured boxes. SBT clusters are as in Fig. 1. MLVA clusters are indicated by VACCs, e.g. VACC1. Strains in which Lpms04 has been sequenced are denoted with an asterisk. [PDF](29 kb) Multiple alignment using TRDB of the Lpms04 tandem repeats in 10 reference strains with 48 bp repeats. All the sequences were aligned against that of ATCC 33152 (Philadelphia-1). The number of repeats is indicated under the strain code. [PDF](267 kb) Comparison of Lpms04 sequences in different strains using the TRDB multiple alignment tool. A consensus repeat (in white type with a blue background at the top of the first panel) was determined using the Philadelphia-1 sequence (ATCC 33152 in Fig. 1). Each repeat observed in the submitted sequences is compared with the consensus and differences are indicated by colours. (a) From top to bottom, sequences of strains ATCC 33152, ATCC 43736 (sg13), EUL004, EUL026 and EUL029 belonging to VACC3 were aligned. (b) From top to bottom, sequences of strains ATCC 33152, EUL157, 'Paris' and ATCC 35289 (sg9) belonging to VACC1 were aligned. [PDF](256 kb) Comparison of Lpms04 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. The colour code for VACC is indicated on the left. [PDF](253 kb) Comparison of Lpms01 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. [PDF](245 kb) Comparison of Lpms13 alleles. The dendrogram was generated using the similarity matrix produced in TRDB. Lpms13_code represents the repeats variability. [PDF](246 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from the reference strains ATCC 33152 (Philadelphia-1), from a patient in the USA and two strains from patients in France and in Greece. [PDF](88 kb) Multiple alignment of Lpms01, Lpms04 and Lpms13 tandem repeat sequences from two reference strains [Chicgo-8 (ATCC 33823 sg7) and 1586-SCT-H (ATCC 43703 sg14)] and two new strains, one from a patient (03-004 NP1) and the other from a hospital water sample (03-011 W1) (Pourcel , 2003). [PDF](142 kb) Characterization of a tandem repeat polymorphism in and its use for genotyping. , 1819-1826.

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