1887

Abstract

Lipophilic yeasts of the genus are associated with several skin diseases, such as pityriasis versicolor, folliculitis, seborrhoeic dermatitis and atopic dermatitis, and are also increasingly associated with catheter-related fungaemia. The cell wall components of pathogenic micro-organisms behave as an antigen and/or ligand of the innate immune response. Live cells of and did not react with an anti--1,2-mannoside antibody. However, they showed a strong hydrophobicity and reactivity with an anti--1,3-glucan antibody compared to those of . The cell wall polysaccharides of and were isolated and their structures analysed by H and C NMR experiments. Both polysaccharides were shown to be -1,6-linked linear galactofuranosyl polymers with a small amount of mannan. The presence of galactomannan on cells of species has not been described previously. The galactomannan did not react with an anti- monoclonal antibody which has specificity for -1,5-linked galactofuranosyl residues. An anti- antibody strongly reacted with the galactomannans of and but did not react with the galactomannans of , or The characteristics of the anti- antibody suggest that there is potential for diagnosis of infections by antigen detection.

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2009-10-01
2020-01-21
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