1887

Abstract

During the course of its infection of the mammalian digestive tract, the entero-invasive, Gram-negative bacterium must overcome various hostile living conditions (notably, iron starvation and the presence of antimicrobial compounds produced ). We have previously reported that bacterial growth during iron deprivation raises resistance to the antimicrobial peptide polymyxin B; here, we show that this phenotype is mediated by a chromosomal gene () encoding a transcriptional regulator from the LysR family. We determined that the product of is a pleiotropic regulator which controls (in addition to its own expression) genes encoding the Yfe iron-uptake system and polymyxin B resistance. Lastly, by using a mouse model of oral infection, we demonstrated that YPTB0333 is required for colonization of Peyer's patches and mesenteric lymph nodes by .

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2009-07-01
2019-10-15
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