1887

Abstract

Bacteria commonly communicate with each other by a cell-to-cell signalling mechanism known as quorum sensing (QS). Recent studies have shown that the Las QS autoinducer -(3-oxododecanoyl)--homoserine lactone (3-oxo-C-HSL) of performs a variety of functions not only in intraspecies communication, but also in interspecies and interkingdom interactions. In this study, we report the effects of 3-oxo-C-HSL on the growth and suppression of virulence factors in other bacterial species that frequently co-exist with in nature. It was found that 3-oxo-C-HSL, but not its analogues, suppressed the growth of in a dose-dependent manner. However, 3-oxo-C-HSL did not exhibit a growth-suppressive effect on , , , and . A concentration of 50 μM 3-oxo-C-HSL completely inhibited the growth of . Additionally, a significant suppression of biofilm formation was demonstrated in exposed to 3-oxo-C-HSL. Our results suggest that the QS autoinducer 3-oxo-C-HSL exerts both bacteriostatic and virulence factor-suppressive activities on alone.

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2009-06-01
2020-08-14
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