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Volume 170, Issue 2

Current understandings of colibactin regulation Open Access

Graphical Abstract

Graphical Abstract

Abstract

The biosynthetic machinery for the production of colibactin is encoded by 19 genes () within the pathogenicity island harboured by many of the B2-phylogroup. Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of + bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. Given the genotoxicity of colibactin and the metabolic cost of its synthesis, the regulatory system governing the cluster is accordingly highly complex, and many of the mechanisms remain to be elucidated. In this review we summarise the current understanding of regulation of colibactin biosynthesis by internal molecular components and how these factors are modulated by signals from the external environment.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): colibactin , colorectal cancer , genotoxin , pks island , regulation and virulence
Funding
This study was supported by the:
  • Wellcome Trust (Award 218518/Z/19/Z)
    • Principle Award Recipient: SofiaSandalli
  • Biotechnology and Biological Sciences Research Council (Award BB/W015781/1)
    • Principle Award Recipient: AndrewJ Roe
  • Biotechnology and Biological Sciences Research Council (Award BB/W015781/1)
    • Principle Award Recipient: EmilyAddington
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-02-05
2024-05-15
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Current understandings of colibactin regulation
Microbiology 170, 001427 (2024); https://doi.org/10.1099/mic.0.001427
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