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Abstract

Bacteria swim using membrane-spanning, electrochemical gradient-powered motors that rotate semi-rigid helical filaments. This primer provides a brief overview of the basic synthesis, structure and operation of these nanomachines. Details and variations on the basic system can be found in suggested further reading.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-01-16
2024-12-13
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References

  1. Johnson S, Furlong EJ, Deme JC, Nord AL, Caesar JJE et al. Molecular structure of the intact bacterial flagellar basal body. Nat Microbiol 2021; 6:712–721 [View Article] [PubMed]
    [Google Scholar]
  2. Santiveri M, Roa-Eguiara A, Kühne C, Wadhwa N, Hu H et al. Structure and function of stator units of the bacterial flagellar motor. Cell 2020; 183:244–257 [View Article] [PubMed]
    [Google Scholar]
  3. Yonekura K, Maki-Yonekura S, Namba K. Building the atomic model for the bacterial flagellar filament by electron cryomicroscopy and image analysis. Structure 2005; 13:407–412 [View Article] [PubMed]
    [Google Scholar]
  4. Kawamoto A, Miyata T, Makino F, Kinoshita M, Minamino T et al. Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries. Nat Commun 2021; 12:4223 [View Article] [PubMed]
    [Google Scholar]
  5. Macnab RM. How bacteria assemble flagella. Annu Rev Microbiol 2003; 57:77–100 [View Article] [PubMed]
    [Google Scholar]
  6. Altegoer F, Bange G. Undiscovered regions on the molecular landscape of flagellar assembly. Curr Opin Microbiol 2015; 28:98–105 [View Article] [PubMed]
    [Google Scholar]
  7. Kojima S, Blair DF. The bacterial flagellar motor: structure and function of a complex molecular machine. Int Rev Cytol 2004; 233:93–134 [View Article] [PubMed]
    [Google Scholar]
  8. Manson MD, Tedesco P, Berg HC, Harold FM, Van der Drift C. A protonmotive force drives bacterial flagella. Proc Natl Acad Sci U S A 1977; 74:3060–3064 [View Article] [PubMed]
    [Google Scholar]
  9. Tan J, Zhang X, Wang X, Xu C, Chang S et al. Structural basis of assembly and torque transmission of the bacterial flagellar motor. Cell 2021; 184:2665–2679 [View Article] [PubMed]
    [Google Scholar]
  10. Baker AE, O’Toole GA. Bacteria, rev your engines: stator dynamics regulate flagellar motility. J Bacteriol 2017; 199: [View Article] [PubMed]
    [Google Scholar]
  11. Cohen-Bazire G, London J. Basal organelles of bacterial flagella. J Bacteriol 1967; 94:458–465 [View Article] [PubMed]
    [Google Scholar]
  12. Apel D, Surette MG. Bringing order to a complex molecular machine: the assembly of the bacterial flagella. Biochimica et Biophysica Acta (BBA) - Biomembranes 2008; 17781851–1858 [View Article] [PubMed]
    [Google Scholar]
  13. Rieu M, Krutyholowa R, Taylor NMI, Berry RM. A new class of biological ion-driven rotary molecular motors with 5:2 symmetry. Front Microbiol 2022; 13:948383 [View Article] [PubMed]
    [Google Scholar]
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