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Graphical Abstract

 Graphical abstract 

 

Abstract

is a human gut symbiont, part of the infant and adult gut microbiota and associated with intestinal and extra-intestinal disorders. mechanisms of adaptation to the gut are strain-specific and underpinned by the capacity of strains to utilize mucin and dietary glycans and produce bacteriocins and adhesins. Several potential mediators underpinning the association between strains and diseases have been identified, including the capacity to elicit a pro- or anti-inflammatory host response and modulate host metabolism, secondary bile acids and tryptophan metabolic pathways. Based on increasing evidence from metagenomics studies in humans and functional investigations and in mouse models, is emerging as a main player in influencing health and disease outcomes from infants to the elderly.

Funding
This study was supported by the:
  • BBSRC (Award BB/X011054/1)
    • Principle Award Recipient: NotApplicable
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/micro/10.1099/mic.0.001383
2023-08-25
2024-04-28
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References

  1. Moore WEC, Johnson JL, Holdeman LV. Emendation of Bacteroidaceae and Butyrivibrio and descriptions of Desulfomonas gen. nov. and ten new species in the genera Desulfomonas, Butyrivibrio, Eubacterium, Clostridium, and Ruminococcus. Int J Syst Bacteriol 1976; 26:238–252 [View Article]
    [Google Scholar]
  2. Togo AH, Diop A, Bittar F, Maraninchi M, Valero R et al. Description of Mediterraneibacter massiliensis, gen. nov., sp. nov., a new genus isolated from the gut microbiota of an obese patient and reclassification of Ruminococcus faecis, Ruminococcus lactaris, Ruminococcus torques, Ruminococcus gnavus and Clostridium glycyrrhizinilyticum as Mediterraneibacter faecis comb. nov., Mediterraneibacter lactaris comb. nov., Mediterraneibacter torques comb. nov., Mediterraneibacter gnavus comb. nov. and Mediterraneibacter glycyrrhizinilyticus comb. nov. Antonie van Leeuwenhoek 2018; 111:2107–2128 [View Article] [PubMed]
    [Google Scholar]
  3. Crost EH, Coletto E, Bell A, Juge N. Ruminococcus gnavus: friend or foe for human health. FEMS Microbiol Rev 2023; 47:fuad014 [View Article] [PubMed]
    [Google Scholar]
  4. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464:59–65 [View Article]
    [Google Scholar]
  5. Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 2016; 351: [View Article] [PubMed]
    [Google Scholar]
  6. Bell A, Brunt J, Crost E, Vaux L, Nepravishta R et al. Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut. Nat Microbiol 2019; 4:2393–2404 [View Article] [PubMed]
    [Google Scholar]
  7. Roblin C, Chiumento S, Bornet O, Nouailler M, Müller CS et al. The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties. Proc Natl Acad Sci 2020; 117:19168–19177 [View Article] [PubMed]
    [Google Scholar]
  8. Henke MT, Brown EM, Cassilly CD, Vlamakis H, Xavier RJ et al. Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus. Proc Natl Acad Sci U S A 2021; 118:e2007595118 [View Article] [PubMed]
    [Google Scholar]
  9. Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 2014; 16:495–503 [View Article] [PubMed]
    [Google Scholar]
  10. Lee J-Y, Arai H, Nakamura Y, Fukiya S, Wada M et al. Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon. J Lipid Res 2013; 54:3062–3069 [View Article] [PubMed]
    [Google Scholar]
  11. Coletto E, Latousakis D, Pontifex MG, Crost EH, Vaux L et al. The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain. Gut Microbes 2022; 14:2073784 [View Article] [PubMed]
    [Google Scholar]
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