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Abstract

Virulence-associated bacterial type III secretion systems are multiprotein molecular machines that promote the pathogenicity of bacteria towards eukaryotic host cells. These machines form needle-like structures, named injectisomes, that span both bacterial and host membranes, forming a direct conduit for the delivery of bacterial proteins into host cells. Once within the host, these bacterial effector proteins are capable of manipulating a multitude of host cell functions. In recent years, the knowledge of assembly, structure and function of these machines has grown substantially and is presented and discussed in this review.

Funding
This study was supported by the:
  • Deutsches Zentrum für Infektionsforschung (Award TTU 06 819)
    • Principle Award Recipient: SamuelWagner
  • Deutsche Forschungsgemeinschaft (Award WA3299/5-1, EXC2124)
    • Principle Award Recipient: SamuelWagner
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-06-13
2024-11-05
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