1887

Abstract

is a halophilic (salt-loving) archaeon that grows in salt concentrations near or at saturation. Although isolated from salted fish a century ago, it was the 1971 discovery of bacteriorhodopsin, the light-driven proton pump, that raised interest in across a range of disciplines, including biophysics, chemistry, molecular evolution and biotechnology. have since contributed to numerous discoveries, such as advances in membrane protein structure determination and the first example of a non-eukaryal glycoprotein. Work on , one of the species used to define Archaea, has also elucidated molecular workings in the third domain. Finally, presents creative solutions to the challenges of life in high salt.

Funding
This study was supported by the:
  • Israel Science Foundation (Award 414/20)
    • Principle Award Recipient: JerryEichler
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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/content/journal/micro/10.1099/mic.0.001327
2023-04-17
2024-04-27
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References

  1. Pfeiffer F, Losensky G, Marchfelder A, Habermann B, Dyall-Smith M. Whole-genome comparison between the type strain of Halobacterium salinarum (DSM 3754T) and the laboratory strains R1 and NRC-1. Microbiologyopen 2020; 9:e974 [View Article] [PubMed]
    [Google Scholar]
  2. Christian JH, Waltho JA. Solute concentrations within cells of halophilic and non-halophilic bacteria. Biochim Biophys Acta 1962; 65:506–508 [View Article] [PubMed]
    [Google Scholar]
  3. Lanyi JK. Salt-dependent properties of proteins from extremely halophilic bacteria. Bacteriol Rev 1974; 38:272–290 [View Article] [PubMed]
    [Google Scholar]
  4. Dassarma S, Kennedy SP, Berquist B, Victor Ng W, Baliga NS et al. Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon. Photosynth Res 2001; 70:3–17 [View Article] [PubMed]
    [Google Scholar]
  5. Ng WV, Kennedy SP, Mahairas GG, Berquist B, Pan M et al. Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A 2000; 97:12176–12181 [View Article] [PubMed]
    [Google Scholar]
  6. Mescher MF, Strominger JL. Purification and characterization of a prokaryotic glycoprotein from the cell envelope of Halobacterium salinarium. J Biol Chem 1976; 251:2005–2014 [PubMed]
    [Google Scholar]
  7. Cline SW, Doolittle WF. Efficient transfection of the archaebacterium Halobacterium halobium. J Bacteriol 1987; 169:1341–1344 [View Article] [PubMed]
    [Google Scholar]
  8. Spudich JL. Variations on a molecular switch: transport and sensory signalling by archaeal rhodopsins. Mol Microbiol 1998; 28:1051–1058 [View Article] [PubMed]
    [Google Scholar]
  9. Oesterhelt D, Stoeckenius W. Rhodopsin-like protein from the purple membrane of Halobacterium halobium. Nat New Biol 1971; 233:149–152 [View Article] [PubMed]
    [Google Scholar]
  10. Henderson R, Unwin PN. Three-dimensional model of purple membrane obtained by electron microscopy. Nature 1975; 257:28–32 [View Article] [PubMed]
    [Google Scholar]
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