1887

Abstract

In recent work we identified genes that confer the slow-growing and antibiotic-resistant small-colony variant (SCV) form of , as associated with the amount of capsule the bacteria produce. In this study we isolated a triclosan-resistant SCV (tr-SCV) and demonstrated that it produces significantly less capsule, an effect that appears to be mediated at the transcriptional stage. As with other SCVs, we found that the tr-SCV produces less toxins, and when compared to both a capsule and an Agr mutant we found the tr-SCV to be significantly attenuated in an insect model of infection.

Funding
This study was supported by the:
  • Saudi Arabian Cultural Bureau
    • Principle Award Recipient: DinaAltwiley
  • Biotechnology and Biological Sciences Research Council
    • Principle Award Recipient: RuthC. Massey
  • Wellcome Trust (Award 212258/Z/18/Z)
    • Principle Award Recipient: RuthC. Massey
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/micro/10.1099/mic.0.001277
2023-01-30
2024-12-04
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