1887

Abstract

Coxiella burnetii is an obligate intracellular pathogen that causes acute and chronic Q fever. C. burnetii grows within a eukaryotic host cell in a vacuole highly similar to a phagolysosome. Found worldwide, this environmentally stable pathogen is maintained in nature via chronic infection of ruminants. Aerosol-mediated infection of humans results in infection and usurpation of alveolar macrophages through mechanisms using a bacterial Type 4B Secretion System and secreted effector proteins. Advances in axenic culture and genetic systems are changing our understanding of the pathogen’s physiology and intimate molecular manipulations of host cells during infection.

Loading

Article metrics loading...

/content/journal/micro/10.1099/mic.0.000707
2018-11-13
2019-12-15
Loading full text...

Full text loading...

/deliver/fulltext/micro/165/1/1.html?itemId=/content/journal/micro/10.1099/mic.0.000707&mimeType=html&fmt=ahah

References

  1. Seshadri R, Paulsen IT, Eisen JA, Read TD, Nelson KE et al. Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc Natl Acad Sci USA 2003;100:5455–5460 [CrossRef][PubMed]
    [Google Scholar]
  2. Beare PA, Samuel JE, Howe D, Virtaneva K, Porcella SF et al. Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons. J Bacteriol 2006;188:2309–2324 [CrossRef][PubMed]
    [Google Scholar]
  3. Beare PA, Unsworth N, Andoh M, Voth DE, Omsland A et al. Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella. Infect Immun 2009;77:642–656 [CrossRef][PubMed]
    [Google Scholar]
  4. Crabill E, Schofield WB, Newton HJ, Goodman AL, Roy CR. Dot/Icm-Translocated proteins important for biogenesis of the Coxiella burnetii-containing vacuole identified by screening of an effector mutant sublibrary. Infect Immun 2018;86: [CrossRef][PubMed]
    [Google Scholar]
  5. Omsland A, Cockrell DC, Howe D, Fischer ER, Virtaneva K et al. Host cell-free growth of the Q fever bacterium Coxiella burnetii. Proc Natl Acad Sci USA 2009;106:4430–4434 [CrossRef][PubMed]
    [Google Scholar]
  6. Beare PA, Heinzen RA. Gene inactivation in Coxiella burnetii. Methods Mol Biol 2014;1197:329–345 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/mic.0.000707
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error